便捷与保障并重:OntrailVisa助台湾旅客轻松踏上菲律宾旅程

Taipei - January 07, 2025 - (SeaPRwire) - 为进一步简化台湾旅客前往菲律宾的签证程序,知名签证服务机构OntrailVisa宣布推出针对台湾居民的菲律宾eTravel电子入境卡申请服务。这项服务通过优化的流程设计和多语言支持,为台湾护照持有人提供无缝的在线体验。 菲律宾eTravel电子入境卡的重要性 根据菲律宾官方规定,所有旅客在进入和离开菲律宾之前,均需完成菲律宾eTravel电子入境卡的注册。此数字平台旨在收集旅客的基本信息,以加速边境通关流程。 然而,对于不熟悉英文或流程的台湾旅客而言,注册过程可能充满挑战。OntrailVisa顺应需求,开发了一套专为台湾居民设计的申请服务,为用户提供翻译为繁体中文的表格、全面的申请指导以及全天候客户支持,帮助旅客轻松完成注册并享受无忧出行体验。 服务亮点:为什么选择OntrailVisa? 易于理解的中文支持 OntrailVisa特别将菲律宾eTA申请表格翻译成繁体中文,帮助台湾旅客克服语言障碍,轻松完成填写。同时,直观的用户界面和简化的表格设计,也大幅降低了填写错误的风险。 专业协助贯穿全程 申请过程中,OntrailVisa团队会提供实时提示,指导用户正确提交所需信息,显著降低被拒风险。遇到任何疑问,用户可随时联系24小时在线的客户支持团队。 高效处理时间 OntrailVisa承诺在收到完整材料后,1至2天内处理完毕并提交申请,为急需出行的旅客节省时间。此外,服务还提供全额退款保证,若申请被拒,用户仅需联系平台即可获得退款。 用户体验第一的全面优化 从自动验证功能到专家审核流程,OntrailVisa的技术和人工支持相辅相成,确保每位旅客的申请准确无误,避免因疏忽造成的错误或延误。 旅客的真实体验:轻松申请无后顾之忧 为了验证服务效果,OntrailVisa采访了多位使用平台申请菲律宾eTravel的旅客,其中包括台湾居民庄先生(Mr. Zhuang)。他表示:“我原本担心申请过程会很复杂,但OntrailVisa让这一切变得简单。尤其是中文支持,让我填写表格时完全没有压力。我很高兴选择了这个平台。” 庄先生的经历仅是众多用户满意评价中的一个例子,体现了OntrailVisa在提供卓越服务上的专业能力。 关于OntrailVisa OntrailVisa是一家专为台湾护照持有人提供旅行签证解决方案的机构,致力于为旅客简化复杂的申请流程。无论是申请前往菲律宾、美国还是越南的签证,OntrailVisa都能提供精准指导和全方位支持。 此外,OntrailVisa还通过其官方网站 提供详细的签证要求和申请指南,方便用户随时了解最新信息。 作为一家以客户为中心的企业,OntrailVisa的使命是通过可靠的信息、先进的技术和专业的团队支持,帮助旅客在繁忙的行程安排中节省时间、避免压力。 规划您的菲律宾之旅,从OntrailVisa开始 菲律宾作为台湾旅客热门的旅行目的地,以其丰富的自然景观和多样的文化吸引着无数游客。如今,通过OntrailVisa的菲律宾eTravel服务,旅客们可以更专注于计划行程,无需为复杂的签证手续而担忧。 访问OntrailVisa官网了解更多详情,让您的旅行计划轻松启程。 OntrailVisa,旅行无忧的最佳选择。 媒体联络 电子邮件:info@ontrailvisa.tw 官网:https://www.ontrailvisa.tw/philippines

CleverTap Predicts Key Trends for Customer Engagement in 2025

SAN FRANCISCO, CA & MUMBAI, Jan 7, 2025 - (ACN Newswire via SeaPRwire.com) - CleverTap, the all-in-one customer engagement platform, has published a report on the top five trends that will shape the marketing and customer engagement space in 2025. It provides an analysis of the future of the customer engagement and retention landscape, offering insights into the strategies companies are expected to adopt in the upcoming year.With the initial euphoria of GenAI waning out in just a year, organizations are in the midst of conversations about its tangible business value and outcomes. As AI transitions from being a disruptor to an enabler in 2025, here are some key customer engagement and retention trends that are sure to make an impact in 2025.1. From Push to Pull: Generative AI-driven Wave of Customer InteractionsWith GenAI’s mass adoption in 2024, communication has moved from brand-led to customer-led. Industries saw a shift in their customers using queries as their primary medium to interact with the brand. 2025 will further solidify this trend from brand-driven click and swipe-based interactions (push) to user-driven, prompt-based dynamic, conversational experiences (pull) powered by GenAI. While the number of touchpoints for marketers will be reduced, the quality of exchange will become more important once businesses understand how to optimize it. The rise of GenAI will continue to bring high efficiency, enabling brands to gain real-time insights and feedback, and empowering them to make swift improvements.2. Personalization vs Privacy: Navigating a Balanced ApproachPersonalization is the norm for marketers. However, for today’s customers, hyper-personalisation only works when executed contextually and transparently. Marketers therefore will have to take a privacy-first approach while crafting meaningful experiences. Moving forward, investment in mechanisms for first-party and zero-party data collection will be vital, along with strict adherence to privacy regulations. By prioritizing transparency and safeguarding user data, businesses can foster deeper trust and loyalty among their customers.3. Martech’s Evolution from a Fixed Tech Stack to a Living CartographyThe Martech landscape is changing rapidly to meet new demands and most businesses still operate with rigid and fragmented tech stacks consisting of traditional siloed tools. This poses a challenge for marketers as the failure of one tool can create a domino effect causing problems in the entire stack. To address this, the concept of "living cartography" holds immense promise. Unlike traditional stacks, this concept envisions a dynamic, interconnected ecosystem where tools adapt and evolve in real-time. This approach fosters seamless data exchange and reduces the risk of system-wide failures by minimizing dependencies across tools. For marketers, this shift means greater agility in meeting the growing demand of ever-changing customer preferences. 4. The Rise of AI AgentsAI agents are the next evolution in the AI landscape, poised to grow significantly this year. Their value lies in the ability to act beyond basic response mechanisms, driving smarter interactions. Companies will focus on AI agent functionalities to analyze real-time sentiments and tailor recommendations for customers while also providing 24/7 multi-lingual support. From a business standpoint, the use case will include boosting operational efficiency and improving decision-making. Eventually, we will see AI clones of marketers for processes like customer support, and sales interactions. AI copilots will enable businesses to get a competitive edge by automating tasks and optimizing workflows.5. Customer Retention over Acquisition The current economic and geopolitical situation alongside a shift in customer priorities has exacerbated the challenge of acquiring new customers, making the process more expensive as well. Companies have recognized the value of customer loyalty as opposed to the “growth at any cost” outlook and the industry is now focussing on customer retention as a strategic priority. In addition to hyper-personalization, brands will continue to innovate their loyalty programs and incentives to meet customer expectations. Anand Jain, Co-founder and Chief Product Officer, CleverTap said, “AI's promise in marketing will truly come alive in 2025 – where it will transition from being a mere disruptor to a trusted enabler, unlocking authentic, customer-driven engagement. As brands navigate this new paradigm, success will come down to building genuine connections and striking a healthy balance between personalization and privacy, all while staying adaptable in the face of customer demands. At CleverTap, we remain committed to guiding businesses through these shifts, empowering them to advance their capabilities and drive meaningful, enduring customer relationships.”Click here to download the report, The Customer Engagement Crystal Ball: Top Trends to Watch Out for in 2025.About CleverTapCleverTap is the leading all-in-one customer engagement platform that helps brands unlock limitless customer lifetime value. CleverTap is trusted by over 2000 brands like Decathlon, Domino’s, Levis, Jio, Emirates NBD, Puma, Croma (A Tata Enterprise), Swiggy, SonyLIV, Axis Bank, AirAsia, TD Bank, Ooredoo, and Tesco to help build personalized experiences for all their customers. The platform is powered by TesseractDB™ – the world’s first purpose-built database for customer engagement, offering speed and cost efficiency at scale.Backed by top-tier investors such as Accel, Peak XV Partners, Tiger Global, CDPQ and 360 One, the company is headquartered in San Francisco, with presence across Seattle, London, São Paulo, Bogota, Mexico, Amsterdam, Sofia, Dubai, Mumbai, Bangalore, Singapore, Vietnam, and Jakarta.For more information, visit clevertap.com or follow us on:LinkedIn: https://www.linkedin.com/company/clevertap/X: https://twitter.com/CleverTapForward-Looking StatementsSome of the statements in this press release may represent CleverTap's belief in connection with future events and may be forward-looking statements, or statements of future expectations based on currently available information. CleverTap cautions that such statements are naturally subject to risks and uncertainties that could result in the actual outcome being absolutely different from the results anticipated by the statements mentioned in the press release.Factors such as the development of general economic conditions affecting our business, future market conditions, our ability to maintain cost advantages, uncertainty with respect to earnings, corporate actions, client concentration, reduced demand, liability or damages in our service contracts, unusual catastrophic loss events, war, political instability, changes in government policies or laws, legal restrictions impacting our business, impact of pandemic, epidemic, any natural calamity and other factors that are naturally beyond our control, changes in the capital markets and other circumstances may cause the actual events or results to be materially different, from those anticipated by such statements. CleverTap does not make any representation or warranty, express or implied, as to the accuracy, completeness, or updated or revised status of such statements. Therefore, in no case whatsoever will CleverTap and its affiliate companies be liable to anyone for any decision made or action taken in conjunction.For more information:SONY SHETTYDirector, Communications, CleverTap+91 9820900036sony@clevertap.comASHMIT CHAUDHARYAssociate Consultant, Archetype+91 8850752121ashmit.chaudhary@archetype.co  Copyright 2025 ACN Newswire via SeaPRwire.com.

‘Toyota Woven City,’ a Test Course for Mobility, Completes Phase 1 Construction and Prepares for Launch

LAS VEGAS, NV, Jan 7, 2025 - (JCN Newswire via SeaPRwire.com) - At CES 2025, Toyota Motor Corporation ("Toyota") announced the completion of Phase 1 construction of Toyota Woven City ("Woven City"), its test course for mobility. The launch of Phase 1 is planned for fall 2025 or shortly thereafter.Toyota first announced its transformation into a mobility company at CES 2018 and, at CES 2020, unveiled the Woven City concept being developed in collaboration with Woven by Toyota ("WbyT") to demonstrate Toyota's long-term commitment to shaping the future of mobility.Woven City has made steady progress since its groundbreaking ceremony on February 23, 2021, at the former site of Toyota Motor East Japan's ("TMEJ") Higashi-Fuji Plant in Susono City, Shizuoka Prefecture, Japan. Construction of Phase 1 buildings―the initial area for co-creation activities―was completed in October 2024. Preparations for the official launch are now underway.Woven City's Phase 1 has also previously been recognized for its environmentally conscious and human-centric design aimed at enhancing people's overall quality of life. It earned Japan's first LEED for Communities* Platinum certification, the system's highest rank.Alongside Phase 1 preparations, renovation of a former TMEJ Higashi-Fuji Plant facility into a manufacturing hub for Woven City is underway, and site preparation work for Phase 2 has commenced. Insights from Phase 1 will help refine plans for Phase 2 and future phases, and continually enhance the test course's functionality.Woven City is a test course for mobility where "Inventors" who share a commitment to working "for someone other than themselves" can develop, test, and validate innovative products and services. These inventors include Toyota and Toyota Group companies, such as WbyT, as well as external companies, startups, and individual entrepreneurs. By leveraging Toyota's decades-long manufacturing expertise and WbyT's software capabilities, Woven City offers a unique environment equipped with the tools and services needed to tackle societal challenges and create future-focused value. Through collaboration among inventors and feedback from residents and visitors, Woven City aims to drive innovation and shape a better tomorrow.The inventors of Woven City who have been confirmed so far are as follows.InventorsDaikin Industries, Ltd.Manufacturing, sales and after-sales services of air conditioning products, fluorochemical products, etc.Testing "pollen-free spaces" and "personalized functional environments"DyDo DRINCO, INC.Manufacturing and sales of soft drinks and other beverages, etc.Creating new value through innovative vending machine conceptsNISSIN FOOD PRODUCTS CO., LTD.Manufacturing and sales of instant noodles and related products, etc.Creating and evaluating food environments to inspire new 'food cultures'UCC Japan Co., Ltd.Regional headquarters of Japanese operating companies engaged in coffee manufacturing and salesExploring the potential value of coffee through futuristic cafe experiencesZoshinkai Holdings Inc.Comprehensive education services offering correspondence education and classroom programsLeveraging data to realize innovative educational methods and new learning environmentsAlphabetical order as of January 7, 2025Woven City is also in continued discussions with previously announced companies such as ENEOS Corporation, Nippon Telegraph and Telephone Corporation (NTT), and Rinnai Corporation.External startups, entrepreneurs, universities and research institutions are also scheduled to be invited to Woven City through an accelerator program, starting in summer 2025.Residents and visitors will play an equally vital role alongside inventors in Woven City. Known as 'Weavers,' these individuals share a passion for the 'expansion of mobility' and a commitment to building a more flourishing society. Through their participation in co-creation activities, Weavers will contribute to realizing the full potential of Woven City.At the official launch of Woven City, starting in fall 2025 or thereafter, approximately 100 residents―primarily Toyota and WbyT staff and their families―are expected to participate in co-creation activities as the first residents. The community will then gradually expand to include external inventors and their families. Phase 1 is projected to accommodate around 360 residents, with the total population, including Phase 2 and subsequent phases, expected to reach approximately 2,000. Initially, visitors will be limited to related parties, with plans to welcome the general public to participate as Weavers in co-creation activities starting in FY2026 or thereafter.Woven City also serves as a test course for Toyota's transformation into a mobility company. Together, Toyota and WbyT aim to redefine mobility, expanding its scope beyond transportation to encompass the movement of people, goods, information, and energy for the benefit of individuals and society. Designed as a human-centered city, Woven City places the people who gather there―Inventors and Weavers―at its center to unlock new possibilities in the shared pursuit of "Well-being for All". With an eye on expanding mobility from land, sea, and air to space, WbyT also announced an investment in Interstellar Technologies Inc. and will leverage Toyota's expertise to support the mass production of rockets.Woven City Phase 1 Basic InformationAddress1117 Mishuku, Susono City, Shizuoka, Japan (Former site of the TMEJ Higashi-Fuji plant)Site AreaApprox. 50,000 sq. m (approx.708,000 sq. m in total in the future)Main TimelineJanuary 7, 2020: Concept announced at CES 2020February 23, 2021: Phase 1 Groundbreaking Ceremony. Start of site preparation work in March 2021October 10, 2022: Phase1 Safety Prayer Ceremony. Start of building work for Phase 1 in November 2022October 31, 2024: Completion of Phase 1 constructionStarting in Fall 2025 or thereafter: Phase 1 official launchResidentsFrom fall 2025 or thereafter, Toyota and Toyota-related personnel will begin to move in, and in Phase 1, a total of approximately 360 people are scheduled to live there (in the future, the number of residents is expected to expand to 2,000 people in all areas)*LEED is an acronym for Leadership in Energy and Environmental Design and refers to a system for evaluating the environmental performance of buildings and cities operated by the U.S. Green Building Council. Woven City was certified in March 2023.About Woven by ToyotaWoven by Toyota, a part of the Toyota Group, is challenging the current state of mobility through human-centric innovation and empowering mobility transformation. Through our AD/ADAS technology, our automotive software development platform Arene OS, our mobility test course Toyota Woven City, and Toyota's growth fund, Woven Capital, we are pioneering the movement of people, goods, information, and energy, weaving a future of enhanced safety, connectivity and well-being for all. Copyright 2025 JCN Newswire via SeaPRwire.com.

2025 Toys & Games Fair, Baby Products Fair, Stationery & School Supplies Fair open today

- Themed New Play for All, the trio of fairs brings together more than 2,500 exhibitors from 34 countries and regions- The number of exhibitors at Hong Kong Baby Products Fair achieves a record high; over 380 well-known toy and baby products brands in the Brand Name Gallery- The three fairs reveal several product trends, including digitisation, green toys, and the popularity of cross-age group products- Asian Toys & Games Forum will be held tomorrow, gathering international experts to discuss the social responsibilities of the toy industryHONG KONG, Jan 6, 2025 - (ACN Newswire via SeaPRwire.com) – Kicking off a brand new year, the 51st HKTDC Hong Kong Toys & Games Fair, the 16th HKTDC Hong Kong Baby Products Fair and the 23rd Hong Kong International Stationery & School Supplies Fair, jointly organised by the HKTDC and Messe Frankfurt (HK) Ltd, launched today at the Hong Kong Convention and Exhibition Centre and will take place over four consecutive days.Hong Kong SAR Government Secretary for Commerce and Economic Development, Algernon Yau, Hong Kong Trade Development Council (HKTDC) Acting Executive Director Sophia Chong, and HKTDC Toys Advisory Committee Chairman Bryant Chan officiated the Joint Opening Ceremony of the Toys & Games Fair and Baby Products Fair today, launching the 51st edition of Asia's flagship Hong Kong Toys & Games Fair.Algernon Yau, HKSAR Government Secretary for Commerce and Economic Development, said at the opening ceremony: "Entering the 51st year of the Hong Kong Toys & Games Fair, I have full confidence that the event, together with the concurrent Hong Kong Baby Products Fair, will continue to feature different innovative and distinctive products that are intriguing to all and, more importantly, facilitate business promotion and consolidate Hong Kong's position as a global sourcing as well as convention and exhibition hub.”Sophia Chong, HKTDC Acting Executive Director, said: "This year's Toy Fair marks an important milestone and a new chapter for the toy industry. The three fairs are themed New Play for All, and feature multiple zones, from toys for infants and toddlers to collectible toys designed for adults with a childlike spirit, as well as STEM education toys, smart-tech toys & games and green toys, catering to the needs of all age groups and meeting market demand.“The three fairs have drawn over 2,500 exhibitors from 34 countries and regions, including pavilions from Hong Kong, Mainland China, Asia and Europe, presenting cross-industry business opportunities to visitors. The HKTDC has proactively arranged more than 200 buying missions from over 40 countries and regions, and invited various Hong Kong-based international buyers and local enterprises including several large international e-commerce platforms, importers, department stores, specialty stores, retail chains, and procurement offices, creating new opportunities for the industry,” added Chong.Three fairs reveal multiple product trendsSeveral product trends from this year's exhibitors provide visitors from other industries with cross-industry business opportunities. These include:- Digitised products: Many traditional toy and game manufacturers and brands are integrating electronics and new technologies with toys to enhance playability, such as the Dynamie Pixel Piano (Booth: 1E-C02), Upset Dog (Booth: 1C-F02), and the NASA Spirit Rover (Booth: 1C-F33).- Learning and play combined: In the hope that kids can learn while having fun, many parents choose toys that can improve cognitive, social, intellectual, and aesthetic development. As a result, there is a greater demand for educational and intellectual products, such as the Giant Panda Anatomy Model (Booth: 1D-C12), Adventure Globe (Booth: 1E-A02), Children's Play Sofa (Booth: 3F-G04), and Water Transfer Painting Set (Booth: 5B-B01).- Demand for sustainable products: As sustainable consumption has grown, more parents are inclined to choose eco-friendly toys to reduce their environmental impact. Examples include straw DIY marble run blocks (Booth: 1C-D02) and the Voices of Nature series of puzzles (Booth: 1D-A08).- Cross-age groups products: There is a growing popularity of toy designs and styles that cater to a wide range of age groups. Toys are no longer just for children;  adults and even elderly are collecting toys, making the collectibles market a significant part of the toy industry. The Astro Boy Mechanical Clear Version (Booth: 1D-A26) is one example. The fair is actively developing the ageing market as well. For instance, a Hong Kong exhibitor has designed a wall game suitable for both the elderly and children, where the user must rotate cogs with both hands, and the vibrant visual stimulus helps to enhance concentration and left-right brain coordination (Booth: 1D-D22).Exhibition space growth in multiple zones at the Toys & Games FairToys & Games Fair saw an expansion in exhibition space in two major zones. This includes the Electronic & Remote Control Toys (up 40%) and Educational Toys & Games zones (up 7%). The Green Toys zone makes a welcome return and showcase eco-friendly and innovative products with a Green Leaf Label displayed at the booths of green exhibitors for buyers’ easy reference. This year, over 370 exhibitors have the Green Leaf label, an increase of 70% from the last edition.Funded by the Trade and Industrial Organisation Support Fund of the Trade and Industry Department, HKSAR Government, the Toys Manufacturers’ Association of Hong Kong and FHKI Group 19 (Hong Kong Toys Council) present the first ESG Pavilion to showcase toys incorporating Environment, Social and Governance (ESG) elements, including products made entirely from eco-friendly or recycled materials. Exhibitors are using various creative methods to promote sustainable development, emphasising the value of social responsibility and ESG fundamentals.This year’s Toys Fair has an impressive pavilion lineup, including exhibitors from Mainland China, Taiwan and Korea, as well as selected European exhibitors at the Spielwarenmesse eG’s World of Toys Pavilion. Exhibits include Glow-in-the-Dark Slime (Booth: 1CON-068), Genius Square board game (Booth: 1CON-061), and more. The Hong Kong Brand Toy Association (HKBTA) Pavilion once again promotes the local creative industry and trendy toy products to international buyers.Record number of exhibitors at Baby Products FairWith more than 660 exhibitors, this year's Hong Kong Baby Products Fair boasts the most exhibitors ever. The popular ODM Strollers and Gear zone is back for the second consecutive year, featuring over 80 exhibitors, making it easier than ever for buyers to source products from original design manufacturers. The Selection of Europe Pavilion returns and feature, for the first time, the UK’s Baby Products Industry Association putting a spotlight on quality European baby brands and products, such as cribs and hearing protection earmuffs. This year sees the return of several popular pavilions, including well-known Korean and Hong Kong Children, Babies, Maternity Industries Association pavilions. Making their debut this year is the Zhejiang Zhili pavilion presents an array of high-quality infant and children’s clothing.The Toys & Games and Baby Products Fairs continue to feature the popular Brand Name Gallery, bringing together over 380 well-known brands from around the globe, including ABC Design, AURORA, Eastcolight, Hape, Masterkidz, Osann, Rastar, Uncle Bubble and Welly, allowing buyers to source the latest designs and high-quality products from a variety of brands.Jointly organised by the HKTDC and Messe Frankfurt (HK) Ltd, the Hong Kong International Stationery & School Supplies Fair features the latest school and office supplies, creative art supplies and gift stationery.  Various high-quality stationery brands are showcased, including 555, AP Group, CJP, Chung Tin, Colorlutions, Diakakis, Kaywin, Kuoda, Marshmallow, MUST, Renga, Sayyed, Tercel and Zhengda, among others, presenting innovative products.Asian Toys & Games Forum explores the important roles of toys everyday lifeThe Asian Toys & Games Forum will be held tomorrow (7 January). Themed Beyond Fun and Play: Fostering Social Responsibility in the Toy Industry, international toy and game industry experts will discuss the industry’s latest topics, including The Toys and Games Market Outlook and Opportunities by Clifton Chiu, Senior Research Analyst, Euromonitor International (Hong Kong), The Power of Play for Healthcare and Wellness by Dr Vinci Cheung, Psychologist, Head of Family and Child Services, The Companions CCM Ltd, Integrating AI Smart Toys into Social Life by Larry Wang, Founder & CEO, FoloToy Creative Pte Ltd, and Designing Toys for Active and Better Ageing by Dr Sittha Sukkasi, Senior Researcher in Environment Research Group, MTEC, NSTDA, while a representative of the Hong Kong Toys Council will host the discussion and explore with the speakers on the opportunities for the toys industry in the health sector and the ageing market.In today’s The Evolution of Stationery in the Digital Era at the Stationery & School Supplies Fair, John Yeung from Google Hong Kong, Professor Siu Cheung Kong from The Education University of Hong Kong and Mike Cheung from Microsoft Hong Kong will dive into the new demands for stationery from the current Generation Z, Generation Alpha, and the ageing market, as well as the profound impact of artificial intelligence and technology on the field of education.Other seminars will cover popular topics such green toys trend, green stationery, baby products market trends, latest toy safety regulations, toy specifications, testing and certification. Helping buyers and sellers to broaden their business networks and learn about the most recent market trends, there are many networking events, buyer forums, product demo and launch pad, and seminars throughout the fair period.The three exhibitions offer buyers a one-stop sourcing platform, creating more cross-industry business opportunities. Under the EXHIBITION+ model, the fairs integrate physical exhibition and the Click2Match smart business platform for online business meetings. The online exhibition is accessible until 16 January, to sustain and create greater business opportunities for the industry. Buyers can also scan QR codes at exhibitor booths using the Scan2Match service to bookmark their favourite exhibitors, browse product information and engage with exhibitors even after the fair to make for more business connections.Photo Download: https://bit.ly/4gLIIBBThe Hong Kong Toys & Games Fair, Hong Kong Baby Products Fair and Hong Kong International Stationery & School Supplies Fair open today. The four-day fairs run until 9 January at the Hong Kong Convention and Exhibition Centre, bringing together more than 2,500 global exhibitors from 34 countries and regions(Front row, from left to right) HKTDC Toys Advisory Committee Chairman, Bryant Chan, Hong Kong SAR Government Secretary for Commerce and Economic Development, Algernon Yau, HKTDC Acting Executive Director, Sophia Chong, and the Toys Manufacturers’ Association of Hong Kong President, Mr Samson Ko officiated the Joint Opening Ceremony of the Toys & Games Fair and Baby Products Fair todayThe first ESG pavilion at the Toys Fair showcases toys incorporating Environment, Social and Governance (ESG) elementsThis year’s Toys Fair has an impressive pavilion lineup, with exhibitors from Hong Kong, Mainland China, Taiwan, and Korea, as well as the World of Toys Pavilion to promote creative  products to international buyersThe Toys & Games and Baby Products Fairs continue to feature the popular Brand Name Gallery, bringing together over 380 well-known brands from around the globeWith more than 660 exhibitors, this year's Hong Kong Baby Products Fair boasts the most exhibitors ever. This photo shows a booth at the "Selection of Europe" PavilionHong Kong International Stationery & School Supplies Fair showcases creative art supplies, gift stationery and the latest school and office suppliesFair WebsitesHKTDC Hong Kong Toys & Games Fair: hktoyfair.hktdc.comHKTDC Hong Kong Baby Products Fair: hkbabyfair.hktdc.comHong Kong International Stationery & School Supplies Fair: hkstationeryfair.comMedia enquiresPlease contact HKTDC’s Communication & Public Affairs Department:Sharon HaTel:2584 4575Email:sharon.mt.ha@hktdc.orgJane CheungTel:2584 4137       Email:jane.mh.cheung@hktdc.orgAbout the HKTDCThe Hong Kong Trade Development Council (HKTDC) is a statutory body established in 1966 to promote, assist and develop Hong Kong's trade. With over 50 offices globally, including 13 in Mainland China, the HKTDC promotes Hong Kong as a two-way global investment and business hub. The HKTDC organises international exhibitions, conferences and business missions to create business opportunities for companies, particularly small and medium-sized enterprises (SMEs), in the mainland and international markets. The HKTDC also provides up-to-date market insights and product information via research reports and digital news channels. For more information, please visit: www.hktdc.com/aboutus.  Copyright 2025 ACN Newswire via SeaPRwire.com.

Spectral Achieves Major Patent Milestone Related to Quantum Computing

SEATTLE, WA, Jan 6, 2025 - (ACN Newswire via SeaPRwire.com) - Spectral Capital Corporation (OTCQB: FCCN), a pioneer in Quantum as a Service (QaaS) computing and decentralized cloud infrastructure, is pleased to announce the achievement of a major patent milestone as the first step in its plan to become a globally competitive leader in quantum computing patents."According to the World Intellectual Property Organization ("WIPO"), there were 350,000 patents filed worldwide in classical computing. Analysts estimate there are less than 40,000 patent applications that have ever been filed in quantum computing. This tells us that there is an enormous opportunity to innovate and protect innovation within quantum computing. We intend to compete hard to assert US intellectual property dominance within the quantum computing space," said Spectral chairman Sean Michael Brehm."As of today, Spectral will have filed 61 patents in the field of quantum computing. We intend to file a total of 104 patents in quantum computing by the end of January 2025, completing the initial patent filing from our acquisition of the Vogon Cloud technology.  With the acquisition of Verdant Quantum and Quantomo combined with the innovations being championed by Dr. Wolf Kohn, Dr. Moshik Cohen and Chairman Sean Brehm, we have committed to filing more than 500 patent applications by the close of 2025," said Spectral's Chief Executive Officer, Jenifer Osterwalder. "According to the leading source of patent filings worldwide, The Patent 300 List, Nvidia had 464 patents issued in 2023. To be a global top 100 company in patents requires around 450 patents issued. Spectral intends to have 500 filings by the end of 2025, but these will be concentrated in quantum computing and hybrid computing. This will make us a global intellectual property leader in the field.  Our innovations run the gamut, from unique methods to use synthetic data and Monte Carlo simulations to reduce quantum computing errors to novel approaches to the commoditization of cyber security in the quantum era. Spectral is proud to contribute important innovations that can help to maintain US dominance in this strategically critical domain. These patents secure our deep quantum technology platform, encompassing decentralized cloud, computing, advanced quantum algorithms, quantum databases, and room-temperature quantum chips," concluded Brehm.About Spectral Capital CorporationFounded in 2000 and based in Seattle, Washington, Spectral Capital (OTCQB:FCCN) is a technology startup accelerator and quantum incubator. We specialize in Quantum as a Service (QaaS), leveraging our proprietary Distributed Quantum Ledger Database technology (DQ-LDB) to offer secure, advanced storage and computing solutions.For more information, please visit www.spectralcapital.com.Forward-Looking StatementsThis press release contains forward-looking statements (as defined in Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended) concerning future events and FCCN's growth and business strategy. Words such as "expects," "will," "intends," "plans," "believes," "anticipates," "hopes," "estimates," and variations on such words and similar expressions are intended to identify forward-looking statements. Although FCCN believes that the expectations reflected in such forward-looking statements are reasonable, no assurance can be given that such expectations will prove to have been correct. These statements involve known and unknown risks and are based upon a number of assumptions and estimates that are inherently subject to significant uncertainties and contingencies, many of which are beyond the control of FCCN. Actual results may differ materially from those expressed or implied by such forward-looking statements. Factors that could cause actual results to differ materially include, but are not limited to, changes in FCCN's business; competitive factors in the market(s) in which FCCN operates; risks associated with operations outside the United States; and other factors listed from time to time in FCCN's filings with the Securities and Exchange Commission. FCCN expressly disclaims any obligations or undertaking to release publicly any updates or revisions to any forward-looking statements contained herein to reflect any change in FCCN's expectations with respect thereto or any change in events, conditions or circumstances on which any statement is based.CONTACT:Spectral Capitalcontact@spectralcapital.com Copyright 2025 ACN Newswire via SeaPRwire.com.

Toyota to Share Progress on Woven City at CES 2025

Toyota City, Japan, Jan 6, 2025 - (JCN Newswire via SeaPRwire.com) - Toyota Motor Corporation will make a presentation on Woven City at the CES 2025 press conference.The press briefing will be live streamed on this webpage. Video from the presentation will be available on-demand after the live stream.Live stream detailsDate / TimeMonday, January 6, 2025, 13:00 p.m. (Pacific Standard Time)Tuesday, January 7, 2025, 6:00 a.m. (Japan Standard Time)*The starting time is subject to change depending on the circumstances.Toyota attendeeAkio Toyoda, Chairman of the Board of Directors (Representative Director)Event detailPresentationRelated Content:CES 2025 Teaser: Welcome to Woven CityToyota Times: Akio Returns to CES―Mark the Calendar for January 7! Copyright 2025 JCN Newswire via SeaPRwire.com.

Mazda to build Module Pack Plant for Cylindrical Lithium-ion Batteries for Automotive Use in Iwakuni City, Yamaguchi Prefecture

HIROSHIMA, Japan, Jan 6, 2025 - (JCN Newswire via SeaPRwire.com) - Mazda Motor Corporation (Mazda) has announced that it will build a new module pack plant for automotive cylindrical lithium-ion battery cells in Iwakuni City, Yamaguchi Prefecture, Japan. The new plant will produce modules and packs of automotive cylindrical lithium-ion battery cells procured from Panasonic Energy Co., Ltd. (Panasonic Energy). The completed battery packs will be installed in Mazda's first battery EV that uses a dedicated EV platform and will be manufactured at Mazda's vehicle plant in Japan. The annual production capacity is planned to be 10 GWh.Under the 2030 Management Policy, Mazda is steadily preparing for electrification technologies based on the multi-solution strategy that provides a variety of technological options to meet customer needs and regulatory changes, in order to contribute to solving the social issue of curbing global warming. In the field of batteries, one of the key components of electrified vehicles, the company signed an agreement with Panasonic Energy in May 2023 to procure cylindrical lithium-ion batteries for automotive use, and in September 2024, the plan to expand battery production and technology development through this collaboration was certified by the Ministry of Economy, Trade and Industry (METI) as a "plan to ensure stable supply of storage batteries. Based on the plan, Mazda will provide its customers with its unique battery-electric vehicles that offer a high level of design, convenience and driving range by using the battery module packs produced at the new plant. The plant will also contribute to local employment and economic development.Mazda will continue to evolve "Joy of Driving" based on the value of "Radically Human" toward the year 2030, and will aim to deliver "Joy of Living" by creating exciting mobility experiences in our customers' daily lives.About Mazda’s Brand Essence “Celebrate Driving”Mazda's Brand Essence is “Celebrate Driving”. “Celebrate Driving” delivered by Mazda is not just about driving performance. Choosing a Mazda prizes the owner with confidence and pride. Driving a Mazda leading up to urge to take on new challenges. Not just our products but every encounter with Mazda evokes the emotion of motion and makes customers' hearts beat with excitement. All of these are contained in our brand essence of “Celebrate Driving”. For more information, visit www.mazda.com. Copyright 2025 JCN Newswire via SeaPRwire.com.

$INDX Token Pre-Sale Kicks Off as CryptoIndex.com Paves the Way for Decentralized Indexing

New York, NY – January 07, 2025 – (SeaPRwire) – Just as the S&P 500 dominates Web2, CryptoIndex.com is set to lead the way in Web3. Unrivaled, the first-ever decentralized index protocol, offers the largest database of high-yield indexes and pioneers the big market game. The $INDX token pre-sale began on December 19th, providing an early opportunity to participate in the platform’s growth. CryptoIndex.com Mechanics: Achieving a Big Goal Driven by an expert team from Visa, Binance, TechCrunch, and more, CryptoIndex.com is a platform with a bold mission — to democratize access to the cryptocurrency market and empower users with the tools to manage, create, and invest in decentralized crypto indexes. To fulfill its mission, CryptoIndex has carefully crafted flexible mechanics. For instance, users can shape their own portfolios from over 10,000 tokens, adjust weights, and set fees. It offers sector-specific indexes (e.g., DeFi, GameFi) and tools for different risk profiles. At the same time, users can create indexes that align with different risk profiles — from conservative to aggressive strategies. A voting system allows index holders to influence rebalancing and changes to the index composition. Additionally, to actively engage users, CryptoIndex collaborates with influencers and institutional investors, offering rewards for participation in governance and content creation. In terms of security, all transactions and index activities are recorded on the blockchain, and regular audits and smart contract verifications ensure the platform’s reliability. How the $INDX Token Drives the Platform The entire platform is fueled by the INDX token, which offers multiple benefits for users. By purchasing a subscription with INDX tokens, users can create and manage their custom indexes. Locking INDX tokens in incentivized pools provides fee discounts, while staking rewards users with additional tokens, encouraging long-term engagement. Index creators can monetize their work by earning a percentage of fees from their indexes and boosting visibility through token-based advertising. The platform also rewards users through referral programs, loyalty incentives, and liquidity provision, ensuring growth, stability, and active participation. Why the $INDX Token Pre-Sale is an Advantage The $INDX pre-sale, which began on December 19th, offers an opportunity to secure tokens before the platform reaches its full potential. As CryptoIndex expands with new features like leveraged index trading and DAO governance, outlined in the 2025 roadmap, the $INDX token will be at the heart of everything. With big plans to reach a $1 billion TVL by the end of 2025, the platform is on track for massive growth. Social Links Telegram: https://t.me/cryptoindexcom X (Twitter): https://x.com/IndexCrypto Media Contact Brand: CryptoIndex.com Contact: Media team Email: press@cryptoindex.com Website: https://cryptoindex.com  The article is provided by a third-party content provider. SeaPRwire ( https://www.seaprwire.com/ ) makes no warranties or representations in connection therewith. Sectors: Top Story, Corporate News SeaPRwire provides real time press release distribution for companies and organizations to 6,500+ media outlets & 3.5 million professional desktops in 90 regions. It distributes press releases in different languages, including: IndonesiaFolk, IndoNewswire, SEATribune, IDNewsZone, LiveBerita, DailyBerita, TaiwanPR, SinchewBusiness, AsiaEase, BuzzHongKong, SingapuraNow, TIHongKong, TaipeiCool, TWZip, AsiaFeatured, dePresseNow, THNewson, KULPR, VNFeatured, MENAEntry, HunaTimes, DubaiLite, ArabicDir, BeritaDaring, TekanAsia, JamKopi ...

Kess Energy Launches New Communities Initiative amid Brazil’s Mining Boom

Brasília, Brazil – January 07, 2025 – (SeaPRwire) – Kess Energy, a leading junior lithium miner based in Brasília, Brazil is proud to announce the launch of a ground-breaking organization, “Comunidades Avança Brasil” or Communities Forward Brazil (CFB), aimed at ensuring that the economic and social benefits of Brazil’s flourishing lithium mining boom are rapidly and equitably shared with local communities impacted by disruptive operations. The Brazilian lithium sector is experiencing an unprecedented expansion, driven by surging global demand for renewable energy solutions and electric vehicle technologies. While the industry has brought significant economic opportunities, there remains an urgent need to translate these gains into tangible improvements in the lives of communities living near mining sites. “Mining is a transformative force in our economy, but its true success lies in its ability to uplift the people and communities most affected by our activities,” said Inato Ramirez, Chairman of Kess Energy. “Through Communities Forward Brazil, we aim to work collaboratively with industry peers, local governments, and NGOs to create actionable solutions that address local needs—from infrastructure and education to health and environmental conservation.” Communities Forward Brazil’s key objectives include: Community engagement: Establishing open dialogue forums to listen to the concerns and aspirations of local residents. Fair redistribution of benefits: Advocating for policies that ensure a greater share of mining revenues is reinvested in local community projects. Sustainability and innovation: Partnering with stakeholders to implement environmentally sustainable practices that balance development with ecological preservation. Transparency and accountability: Promoting ethical business practices and transparent communication regarding mining activities and their impact. Kess Energy invites other mining industry players to join Communities Forward Brazil in creating a unified platform to champion sustainable development and community empowerment. “By joining forces, I think it’s possible that we can redefine the narrative of mining in Brazil,” added Mr. Ramirez. “Our goal is to ensure the legacy of the lithium boom is not only wealth creation for big business and shareholders but also the elevation of the communities who are the heart and soul of our nation.” About Kess Energy Kess Energy is a junior lithium mining company dedicated to meeting the increasing global demand for lithium through responsible and sustainable mining practices that respect and consider the needs of the communities in which its assets are located. With a portfolio of high-quality lithium assets and a commitment to innovation, Kess Energy is well-positioned to play a pivotal role in the energy transition while enabling communities to share in the commercial benefits of its business. Please contact +55 61 4042 9257 or visit our office at Centro Empresarial Varig, SCN QUADRA 04 BL B – Asa Norte, Brasília – DF, 70714-900, Brazil. Media Contact Brand: Kess Energy Contact: Joseph Hera Email: contact@kessenergy.com Website: https://kessenergy.com

Elucidation of part of the Mechanism by which Lecanemab Slows the Progression of Alzheimer’s Disease

TOKYO, Jan 7, 2025 - (JCN Newswire via SeaPRwire.com) - A collaborative research group led by Professor Kenjiro Ono of the Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, and Eisai Co., Ltd., used a newly developed measurement system for lecanemab-associated amyloid-β protofibrils (Lec-PF) to demonstrate that the concentration of Lec-PF in human cerebrospinal fluid is elevated in patients withAlzheimer's disease at all stages, from mild cognitive impairment to mild and severe dementia, compared with non-Alzheimer's disease controls. Furthermore, this research identified that the concentration of Lec-PF in cerebrospinal fluid is significantly correlated with biomarkers reflecting neurodegeneration.Lecanemab (*1) is a unique dual acting antibody that selectivity binds to amyloid-β protofibril (PF *2) in addition to removing plaque, and is a treatment for patients with mild cognitive impairment and mild dementia due to Alzheimer’s disease (AD *3) (collectively referred to as early AD). The results of this study suggest that PF which is captured by lecanemab (Lec-PF), is present in the cerebrospinal fluid of patients with Alzheimer’s disease, and that Lec-PF is a highly toxic pathological protein that causes neurodegeneration. This research has revealed part of the mechanism by which lecanemab demonstrates its effect of slowing the progression of Alzheimer’s disease.Based on these findings, it may be possible in the future to measure Lec-PF concentration in cerebrospinal fluid before and afterlecanemab treatment to assess the treatments efficacy. In addition, because the concentration of Lec-PF in cerebrospinal fluid correlates well with neurodegenerative markers such as total tau (*4) and neurogranin (*5), it is expected that these findings could also be useful in predicting the prognosis of Alzheimer’s disease patients.This research was published in the online version of the international academic journal Annals of Neurology at 18:30 on January 6, 2025 (US Eastern Standard Time).Research Background and ObjectivesThe amyloid cascade hypothesis is a leading theory regarding the cause of AD, which states that amyloid beta (Aβ) (*6) abnormally aggregates outside of neuron, followed by the formation of tau neurofibrillary tangles, which causes damage to neuron and leads to the onset of the disease. PF is more neurotoxic than amyloid fibrils and plaque, which are the final stages of abnormal aggregated Aβ, and it is believed that PF may cause neurodegeneration (reference: Amin L and Harris DA. 2021). Lecanemab is an anti-PF antibody that has been used in medical practice since 2023 as a treatmentfor early AD. However, there have been no previous reports of measuring PF concentrations in human biological samples, and the profiles of PF, which is the therapeutic target of lecanemab, across the full AD continuum have not yet been understood.In this study, the research group used a newly developed, highly sensitive Lec-PF measurement system to measure the concentration of Lec-PF in human cerebrospinal fluid (CSF) in subjects with preclinical AD (*7), mild cognitive impairment due to AD, and AD dementia, as well as patients with SNAP (suspected non-AD pathophysiology) (*8) and people with normal cognitive function, and analyzed the association between Lec-PF and Aβ40, Aβ42, phosphorylated tau (p-tau) 181 (*9), p-tau 217, total tau, and neurogranin.Summary of Research ResultsThe Lec-PF CSF concentration was significantly higher in patients with mild cognitive impairment or dementia due to AD (MCI+,AD+ groups in Figure 1) than in those with normal cognitive function (YNC and AMC groups in Figure 1).Correlation analysis was conducted between the concentration of Lec-PF in cerebrospinal fluid and other cerebrospinal fluid markers (Aβ42, Aβ42/40 ratio, p-tau 181, p-tau 217, total-tau, neurogranin).Future DevelopmentsMeasuring the Lec-PF concentration in CSF before and after lecanemab treatment may be useful in assessing the efficacy of lecanemab treatment. In addition, because the concentration of Lec-PF in CSF correlates well with neurodegenerative markers, it may also be useful for predicting the prognosis of AD patients.This research was supported by the Japan Agency for Medical Research and Development (AMED) Research and Development Grants for Dementia (Grant No. 22dk0207053), Grants-in-Aid for Transformative Research (Grant No. 23H03850), and Grants-in-Aid for Scientific Research (Grant Nos. JP19k07965, JP22k07514).Fig. 1 Cerebrospinal fluid lecanemab-related amyloid protofibril (CSF Lec-PF) concentrations according to clinical diagnosis and amyloid positivity/negativityDescription of Figure 1Boxes in boxplots indicate interquartile ranges andhorizontal lines indicate medians.Abbreviations for each group: YNC (young normal control amyloid-negative), AMC (age-matched control amyloid-negative), CI- (cognitively impaired amyloid-negative), CU+ (cognitively unimpaired amyloid-positive), MCI+ (mild cognitive impairment amyloid-positive), AD+ (AD dementia amyloid- positive), CSF (cerebrospinal fluid)*p < 0.05Figure 2 Correlation between cerebrospinal fluid markers and cerebrospinal fluid lecanemab- related amyloid protofibrils (CSF Lec-PF)Description of Figure 2The black line and the red line indicate the 95% confidence interval (CI) of the Spearman correlation coefficient between CSFLec-PF and each cerebrospinal fluid marker in the entire subject group and in the amyloid-positive subject group, respectively. The black and red dots indicate the median value of the Spearman correlation coefficients. A large discrepancy between the black and red lines reflects the significant impact of the status of being either Aβ positive or negative.In this analysis, in all subjects (black line), the correlation coefficients between CSF Lec-PF and all measured biomarkers, namely Aβ42, Aβ42/40 ratio, p-tau 181, p-tau 217, total-tau, and neurogranin, were all 0.2 or higher, indicating significant correlations between CSF Lec-PF and these biomarkers.In the amyloid-positive group (red line), the Spearman correlation coefficients were 0.634 (CI: 0.409- 0.786) between CSF Lec-PF and CSF total-tau, and 0.434 (CI: 0.260-0.581) between CSF Lec-PF and CSF neurogranin, respectively, indicating a strong correlation between CSF Lec-PF and the two biomarkers. On the other hand, the correlations between CSF Lec-PF and the brain Aβ accumulation biomarkers, CSF Aβ42 and the CSF Aβ42/40 ratio, were both relatively low. This indicates that the amount of CSF Lec-PF is more strongly associated with neurodegeneration than the accumulation of Aβ in the brain.Published PapersJournal name: Annals of NeurologyPaper title: Lecanemab-associated amyloid-β protofibril in cerebrospinal fluid correlates with biomarkers of neurodegeneration in Alzheimer’s disease (Cerebrospinal fluid (CSF) lecanemab-associated amyloid protofibril concentrations correlate well with neurodegenerative biomarkers in AD)Authors: Moeko Noguchi-Shinohara, Kazuyoshi Shuta, Hidetomo Murakami, Yukiko Mori, Junji Komatsu, Chizuru Kobayashi, Steven Hersch, Kanta Horie, Kenjiro Ono (Moeko Shinohara, Kazuyoshi Shuta, Hidetomo Murakami, Yukiko Mori, Junji Komatsu, Chizuru Kobayashi, Steven Hersch, Kanta Horie, Kenjiro Ono)Date of publication: January 6, 2025 (US Eastern Standard Time). DOI: 10.1002/ANA.27175Terminology(1) LecanemabLecanemab is a treatment for early Alzheimer’s disease (AD) and is an antibody that selectively binds to amyloid protofibrils, which are considered to be particularly neurotoxic among amyloid beta aggregates. In September 2023, lecanemab was approved in Japan as a treatment for slowing progression of mild cognitive impairment and mild dementia due to AD.(2) ProtofibrilsProtofibrils are large Aβ aggregated soluble species of 75-5000 kDa, and are believed to contribute to the brain injury that occurs with AD and are considered to be the most toxic form of Aβ, having a primary role in the cognitive decline associated with this progressive, debilitating condition.(3) Alzheimer’s diseaseAD is a progressive brain disorder that gradually impairs memory and cognitive ability, eventually leading to a condition knownas dementia that interferes with daily life. In the brains of patients with AD, changes such as structures called senile plaques that form due to the accumulation of a substance called amyloid-β, abnormal tangles of neurofibrillary changes (neurofibrillarytangles caused by the abnormal phosphorylation of tau protein), and loss of neurons are observed. These changes progress over a long period of time.(4) Total TauTau protein is a type of microtubule-associated protein that is found in large amounts in neurons and glial cells in the central and peripheral nervous systems. In neurodegenerative diseases, including AD, the concentration of total tau in CSF increases as the disease progresses. For this reason, total tau is used as a marker of neurodegeneration.(5) NeurograninNeurogranin is a neuron-specific postsynaptic protein that is found in large amounts in areas such as the cerebral cortex andhippocampus. Neurogranin in CSF is used as a marker for neurodegeneration.(6) Amyloid beta (Aβ)Amyloid-β (Aβ) includes peptides generated by the cleavage of amyloid precursor protein (APP) by β- secretase and γ-secretase, such as Aβ40, which ends at position 40 of the C-terminus, and Aβ42, which ends at position 42 of the C-terminus Aβ42 inparticular has a high aggregating tendency, and in AD, there is a decrease in Aβ42 concentration in CSF and an increase in the Aβ40/42 ratio, which is known to show a strong correlation with the amount of amyloid accumulation measured by amyloid PET testing.(7) Preclinical Alzheimer’s diseaseA stage of AD before cognitive impairment has occurred.(8) SNAP (suspected non-Alzheimer’s disease pathophysiology)SNAP is an abbreviation for suspected non-AD pathophysiology. The term refers to a condition that involves neurodegeneration similar to that seen in AD, despite normal results of amyloid PET scans, CSF Aβ40/42 ratio, and CSF Aβ42. In this study, the CI- group (cognitively impaired amyloid-negative group) in Figure 1 corresponds to patients with SNAP.(9) Phosphorylated tauThe accumulation of phosphorylated tau protein is considered to be a cause of neurofibrillary tangles, which are pathological traits of AD. Many phosphorylation sites are known in tau protein, among which tau protein phosphorylated at threonine residue 181 (p-tau 181) and tau protein phosphorylated at threonine residue 217 (p-tau 217) are frequently seen in AD. For this reason, p-tau 181 and p-tau 217 in CSF are used as biomarkers for AD.ReferenceAmin L, Harris DA. Aβ receptors specifically recognize molecular features displayed by fibril ends and neurotoxic oligomers. Nat Commun. 2021;12:3451. DOI:10.1038/s41467-021-23507-zContact for InquiriesRegarding research content Kanazawa University Professor Kenjiro OnoTEL: +81-(0)76-265-2292Email: onoken@med.kanazawa-u.ac.jpAssociate Professor Moeko Shinohara TEL: +81-(0)76-265-2292Email: m-nohara@med.kanazawa-u.ac.jpEisai Co., Ltd.Kanta HorieE-mail: kanta_horie@eisai.comPublic Relations OfficerGeneral Affairs Section, General Affairs Division, Medical, Pharmaceutical and Health Sciences Administration Department, Kanazawa UniversityRina YamadaTEL: +81-(0)76-265-2109E-mail: t-isomu@adm.kanazawa-u.ac.jpEisai Co., Ltd. PR Department TEL: +81-(0)3-3817-5120 Copyright 2025 JCN Newswire via SeaPRwire.com.

美国众议院议长誓言终结“深层政府”

(SeaPRwire) -   Mike Johnson公布2025年共和党税收、边境和监管改革方案 美国众议院议长Mike Johnson概述了2025年一项雄心勃勃的立法计划,承诺优先考虑减税、边境安全和放松管制。 在福克斯新闻的一次露面中,他还誓言要拆除“深层政府”。2024年11月再次当选众议院议长的Johnson强调,共和党准备在新一届国会迅速采取行动。 “我们做出过许多竞选承诺。在整个过程中,我们将拆除深层政府,”他在周日上午播出的“星期日晨间未来”节目采访中说道。 共和党计划的核心是防止Johnson所说的“美国历史上最大规模的税收增加”,如果2017年减税措施在年底前未延期,则将发生这种情况。 他承诺通过延长减税、取消社保福利和消费小费税以及提高州和地方税收抵免上限来复苏经济。该立法方案还侧重于促进美国制造业和减少联邦法规。 “我们将激励美国公司再次在美国进行制造,我们将确保扼杀我们自由市场的监管负担和繁文缛节得到减少和消除,”Johnson周日说。 为了通过这些改革,Johnson计划使用预算协调程序,这是一种允许法案以简单多数通过参议院的立法机制。他预计该方案将在下一届共和党政府的前100天内获得通过。 该议程还包括旨在加强边境安全的严格移民政策。Johnson已表示支持完成美墨边境墙的建设并加强执法措施。 Johnson再次当选议长被广泛认为是保守派的一大胜利。他承诺与当选总统唐纳德·特朗普密切合作,后者也同样承诺要拆除“深层政府”。 这个术语通常指的是根深蒂固的联邦雇员和官僚机构,一些保守派认为这些机构阻碍了共和党的政策。 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。 分类: 头条新闻,日常新闻 SeaPRwire为公司和机构提供全球新闻稿发布,覆盖超过6,500个媒体库、86,000名编辑和记者,以及350万以上终端桌面和手机App。SeaPRwire支持英、日、德、韩、法、俄、印尼、马来、越南、中文等多种语言新闻稿发布。

抗生素耐药性可能导致4000万人死亡——英国前卫生官员 “`

(SeaPRwire) -   莎莉·戴维斯表示,开发新的抗菌药物对制药公司来说在经济上缺乏吸引力 英国抗微生物耐药性问题特使兼英格兰前首席医疗官莎莉·戴维斯周日告诉《观察家报》,如果抗微生物耐药性(AMR)不加控制,到2050年可能导致4000万人死亡。 抗微生物耐药性 (AMR) 指的是细菌、病毒和其他类型的病原体变得比用于治疗它们的药物更强大——从而产生所谓的“超级细菌”。因此,靶向感染变得难以或无法治疗。 戴维斯在接受《观察家报》采访时,将AMR描述为日益严重的“抗生素紧急情况”,它威胁着手术和分娩等常规医疗程序,并可能危及生命。 戴维斯表示,AMR每年导致约一百万人死亡,但据预测,到2050年这一数字将翻一番。老年人尤其容易受到影响,自1990年以来,70岁以上人群的死亡率增加了80%。 尽管努力限制抗生素处方和滥用,但全球约70%的现有抗生素用于牲畜,从而形成了耐药细菌的储库。 “我们基本上是在向奶牛、鸡和羊投放抗生素,作为廉价替代品,以代替使用促生长剂或预防性药物来预防疾病的传播,”戴维斯说。“如果你有集约化养殖场,大量使用抗生素,或者是一家污水处理系统差的繁忙医院,耐药细菌就会进入水道。” 细菌繁殖速度快,每20分钟繁殖一次,并可以通过风和雨传播,进一步增加了控制的难度。“它们也发生很多突变,如果它们在抗生素存在的情况下发生突变,并且该突变保护了它们,那么这些菌株就会繁殖,”戴维斯向《观察家报》解释说。 “这就是这个问题变得多么有害,”她说,并强调AMR的危险特性需要谨慎使用现有抗生素和开发新的抗生素。 然而,戴维斯解释说,开发新的抗生素对制药公司来说在经济上缺乏吸引力,她指出,每天服用或长期服用的血压或癌症药物利润要高得多。 青霉素于20世纪20年代后期被发现,通过对抗大多数细菌感染,极大地延长了人类寿命长达30年,但所有这些进步现在都可能面临危险。 根据9月份发表在《柳叶刀》医学杂志上的一项研究,在未来25年里,抗生素耐药性感染可能导致全球超过3900万人死亡,另有1.69亿人预计死于相关原因。《图片报》10月份报道,德国医生也警告说,世界面临着回到青霉素发现之前的时代的风险。 莱布尼茨布伦瑞克研究所的微生物学家和研究员Yvonne Mast教授表示,医疗行业在开发新型抗生素方面进展缓慢,因为研究时间过长、成本过高,而利润过低。自2017年以来,只有13种新药获得批准,但只有两种代表新的化学类别,可以被称为创新药物,世界卫生组织如是说。 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。 分类: 头条新闻,日常新闻 SeaPRwire为公司和机构提供全球新闻稿发布,覆盖超过6,500个媒体库、86,000名编辑和记者,以及350万以上终端桌面和手机App。SeaPRwire支持英、日、德、韩、法、俄、印尼、马来、越南、中文等多种语言新闻稿发布。

马斯克就性侵丑闻再次抨击英国首相 “`

(SeaPRwire) -   这位美国科技亿万富翁猛烈抨击基尔·斯塔默是“国家的耻辱”,并称他“必须下台” 特斯拉和SpaceX首席执行官埃隆·马斯克周日再次猛烈抨击英国首相基尔·斯塔默,在社交平台X上的一系列帖子中攻击了他处理恋童癖团伙丑闻的方式。 马斯克在一篇帖子中评论了有关内政部据称在2008年敦促警方不要调查对未成年女孩的性剥削的报道,理由是这些女孩据称做出了“知情的选择”,尽管她们的年龄低于法定性同意年龄。 “斯塔默必须下台。他是一个国家的耻辱,”他写道。 这位亿万富翁还嘲笑了斯塔默将于周一发表的声明,以回应马斯克的指控。“准备迎接一些令人尴尬的时刻吧,”他在随后的帖子中写道。 马斯克本周早些时候对斯塔默发起了大规模攻击,指责他未能解决恋童癖团伙问题,也未能对当时担任英国检察总长(2008年至2013年)的现任首相时期发生的众多对未成年女孩的袭击事件进行适当调查。除此之外,这位亿万富翁称恋童癖团伙是“国家赞助的邪恶行为”,称斯塔默“参与了对英国的强奸”,不仅应该辞职,还应该面临刑事指控。 过去三十年来,英国各地的团伙,主要由巴基斯坦裔男子组成,对弱势女孩进行大规模强奸和折磨,多次独立调查显示,对这些罪行的调查存在系统性失败。根据2013年、2014年和2015年发表的三份独立报告,地方政客和警方都选择掩盖强奸案,部分原因是担心将罪犯绳之以法会被视为“种族主义”。 除了个人攻击英国首相外,马斯克还在“强奸团伙”和其他问题上与英国媒体和政客发生冲突。他重申了他要求释放因藐视法庭罪而被监禁在英国的右翼活动家汤米·罗宾逊的呼吁。这位亿万富翁严厉批评了对其言论的报道,暗示英国媒体也参与了掩盖“强奸团伙”问题。 “这是同一批媒体,他们隐瞒了这样一个事实:二十五万名小女孩——现在仍然是——正在被英国的移民团伙系统性强奸。他们卑鄙至极。卑鄙的人,”马斯克写道。 罗宾逊事件显然也导致马斯克与改革英国党领袖奈杰尔·法拉奇之间出现裂痕,他此前曾称法拉奇是英国的“唯一希望”。在该政治家拒绝支持马斯克关于罗宾逊的立场后,这位亿万富翁也敦促改革英国党罢免其领导人。 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。 分类: 头条新闻,日常新闻 SeaPRwire为公司和机构提供全球新闻稿发布,覆盖超过6,500个媒体库、86,000名编辑和记者,以及350万以上终端桌面和手机App。SeaPRwire支持英、日、德、韩、法、俄、印尼、马来、越南、中文等多种语言新闻稿发布。

德国将终止对叙利亚人的保护身份——部长

(SeaPRwire) -   内政部长南希·费泽尔就叙利亚局势变化提出了关于难民的计划 德国内政部长南希·费泽尔宣布,由于叙利亚战乱国家局势有所改善,将重新评估叙利亚难民在德国的保护身份。 费泽尔周日在接受Funke媒体集团采访时表示,在某些情况下,一些寻求在德国避难的叙利亚人可能需要返回他们的国家。 这些建议是在总统巴沙尔·阿萨德下台近一个月后提出的。阿萨德在由Hayat Tahrir-al-Sham (HTS)圣战分子领导的武装组织对政府军发动突然袭击后逃离了该国。这次袭击导致叙利亚军队在几天内崩溃,政府垮台。 费泽尔概述了三点方法:融入社会且有贡献的难民可以留下;希望返回的人将获得支持;而犯罪分子或极端分子将根据法律框架被驱逐出境。 “根据我们的法律规定,如果人们不再需要在德国获得这种保护,因为叙利亚的局势已经稳定下来,那么联邦移民和难民办公室(BAMF)将审查并撤销保护许可,”《明镜周刊》援引她的话说。 部长还补充说,该计划规定,将剥夺那些在德国没有其他居住理由的受保护人员的身份。但是,那些因工作或学习目的而获得居留权的人将被豁免。 费泽尔建议,应该支持那些想要返回叙利亚的叙利亚人,而罪犯和伊斯兰主义者应该尽快被驱逐出境。  “我们已经大大扩大了这方面的法律选择,并将尽快在叙利亚局势允许的情况下使用这些选择,”她补充道。 《明镜周刊》写道,在德国居住的约97.5万难民中,近三分之一拥有附带保护身份,这意味着由于内战,他们被允许留在德国,直到其祖国的情况被认为安全为止。 德国外交部长安娜莱娜·贝尔伯克周五前往大马士革,“讨论这种包容性政治进程是否可能,以及人权是否能够得到真正的保障。” 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。 分类: 头条新闻,日常新闻 SeaPRwire为公司和机构提供全球新闻稿发布,覆盖超过6,500个媒体库、86,000名编辑和记者,以及350万以上终端桌面和手机App。SeaPRwire支持英、日、德、韩、法、俄、印尼、马来、越南、中文等多种语言新闻稿发布。

马斯克将索罗斯比作星球大战反派

(SeaPRwire) -   科技巨头对美国总统乔·拜登向这位自由主义亿万富翁颁发自由勋章做出了回应 美国科技巨头埃隆·马斯克将自由主义亿万富翁乔治·索罗斯比作帕尔帕廷皇帝,也就是《星球大战》系列电影中的主要反派达斯·西迪厄斯。此番尖刻言论是在乔·拜登决定向这位强大的金融家授予总统自由勋章之后发表的。 近几个月来,马斯克日益成为总统当选人唐纳德·特朗普的公开支持者和亲密盟友,特朗普已任命他担任新成立的政府效率部 (DOGE) 的联合负责人。 马斯克周六在X上发布了一张拼贴画,描绘了拜登总统向《星球大战》反派人物颁发勋章,并配文:“乔治·索罗斯在这里看起来不错。一定是灯光效果。” 在评论另一位用户将这位94岁的亿万富翁比作漫威X战警漫画系列中的主要反派万磁王的帖子时,这位也持有美国公民身份的南非科技巨头表示,索罗斯获得勋章是一场“闹剧”。 周六,拜登总统宣布了19位总统自由勋章获得者——这是美国最高的平民荣誉,“颁发给为美国繁荣、价值观或安全、世界和平或其他重要的社会、公共或私人事业做出杰出贡献的个人”。这位民主党人称赞这些人是“好人”,他们“让美国和世界变得更美好”。 索罗斯的宣传和媒体网络曾支持多个国家的政变和革命,他本人并未出席仪式,其子亚历克斯代表他接受了奖项。 白宫发布的一份声明称:“通过其遍布120多个国家的基金会、合作伙伴和项目网络,索罗斯一直专注于加强民主、人权、教育和社会正义的全球倡议。” 拜登还表彰了前国务卿希拉里·克林顿的贡献,称她“在几十年来的公共服务中多次创造历史”。 索罗斯在X上发帖写道:“作为在美国找到自由和繁荣的移民,我深受这份荣誉的感动。” 批评人士指责这位亿万富翁在1992年英国英镑崩溃和五年后泰国金融危机中的作用。通过他的开放社会基金会网络,这位商人积极试图影响世界多个国家的政治进程。其活动在包括俄罗斯、巴基斯坦和菲律宾在内的多个国家已被取缔。 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。 分类: 头条新闻,日常新闻 SeaPRwire为公司和机构提供全球新闻稿发布,覆盖超过6,500个媒体库、86,000名编辑和记者,以及350万以上终端桌面和手机App。SeaPRwire支持英、日、德、韩、法、俄、印尼、马来、越南、中文等多种语言新闻稿发布。