TOKYO, September 8, 2025 - (JCN Newswire via SeaPRwire.com) - Eisai Co., Ltd. (Headquarters: Tokyo, CEO: Haruo Naito, “Eisai”) announced today that the results from a Phase Ib clinical trial (NCT06462404) of its in-house developed novel selective orexin 2 receptor agonist E2086 have been presented at the World Sleep 2025 congress, held in Singapore from September 5 to 10. These data demonstrate that once-daily dosing of E2086 has the potential to improve daytime wakefulness in individuals with narcolepsy type 1 (NT1). Clinical Trial DesignThis randomized, double-blind, single-dose, multiple crossover, Phase Ib clinical trial was conducted in the United States and Canada to evaluate the efficacy, safety, and tolerability of E2086 in people meeting criteria for NT1, compared with placebo and an existing treatment (modafinil). There were a total of 21 patients in the clinical trial (21 patients received the study medication, 19 patients completed the trial). Participants received a single dose of one of five treatments (E2086 5 mg, 10 mg, 25 mg, placebo, ormodafinil) shortly after waking, efficacy assessments were conducted for each treatment.Efficacy was assessed using the objective Maintenance of Wakefulness Test (MWT)*1 to evaluate excessive daytime sleepiness (EDS), and subjective sleepiness was measured using the Karolinska Sleepiness Scale(KSS)*2 at the end of each MWT session.Clinical Trial ResultsAs evaluated by MWT, all doses of E2086 demonstrated statistically significant longer sleep latencies*3 – a measure of the ability to stay awake – compared with placebo (P<0.0001 for all doses) and modafinil (E20865 mg: P=0.0009; E2086 10 mg and 25 mg: P<0.0001) (See the figure below). For the KSS, all doses of E2086 showed statistically significant higher alertness compared with placebo(P<0.0001), while E2086 10 mg and 25 mg demonstrated statistically significantly higher alertness compared with modafinil (P<0.0001). These outcomes confirmed the Proof of Mechanism for E2086.Treatment-emergent adverse events (TEAEs), based on the 21 patients who received the study medication in the clinical trial, exhibited a dose-dependent trend. The four most frequently observed TEAEs with E2086 included increased urinary frequency (E2086 5 mg: 14.3%, 10 mg: 23.8%, 25 mg: 52.4%), nausea (14.3%,19.0%, 47.6%), dizziness (4.8%, 23.8%, 38.1%), and urinary urgency (9.5%, 19.0%, 38.1%). No participants discontinued due to TEAEs, and most TEAEs were mild to moderate in severity. No serious TEAEs were reported.Katsutoshi Ido, Ph.D., Chief Scientific Officer at Eisai, commented: “At World Sleep 2025, we presented data supporting the potential of E2086 to improve daytime wakefulness in people diagnosed with narcolepsy type 1. Narcolepsy is a condition with high unmet medical needs, characterized not only by excessive daytime sleepiness but also by symptoms such as cataplexy, hypnagogic/hynopompichallucinations, and sleep paralysis, all of which significantly impair the quality of life of those affected. The efficacy and safety findings from this trial warrant further investigation in the narcolepsy patient population.”Orexin is a neurotransmitter that plays a central role in regulating sleep and wakefulness. Inhibiting orexinergic neurons is believed to promote a natural transition from wakefulness to sleep. Conversely, activating orexinergic neurons is believed to help maintain a more stable state of wakefulness. From the perspective of inhibiting orexinergic neuron activity, Eisai has developed the insomnia treatment DAYVIGO® (generic name: lemborexant) an orexin receptor antagonist that is available in more than 25 countries worldwide. Furthermore, leveraging the orexin platform established through the development of DAYVIGO, Eisai has created E2086, an orexin receptor agonist that activates orexinergic neurons. In addition to DAYVIGO, Eisai aims to contribute to people living with sleep disorders through the development of E2086.*1 Maintenance of Wakefulness Test (MWT): An objective test that evaluates the ability to stay awake in a sleep-conducive environment. The test is conducted in a quiet examination room with the lights turned off, consisting of four 40-minute sessions carried out at two-hour intervals throughout the day, during which the time taken to fall asleep (sleep latency) is measured using electroencephalography.*2 Karolinska Sleepiness Scale (KSS): A simple subjective scale used to assess the current intensity of sleepiness ona 9-point scale, ranging from "1 - Very clearly awake" to "9 - Very sleepy, struggling against sleepiness”.*3 Sleep latency: The amount of time it takes to fall asleep.For more details, please visit: https://www.eisai.com/news/2025/pdf/enews202562pdf.pdfMEDIA CONTACTS:Eisai Co., Ltd.Public Relations Department,TEL: +81-(0)3-3817-5120Eisai Europe, Ltd.EMEA Communications Department+ 44 (0) 797 487 9419Eisai Inc. (U.S.)Libby Holman+ 1-201-753-1945  Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

TOKYO, Japan, September 8, 2025 - (JCN Newswire via SeaPRwire.com) – Honda Motor Co., Ltd. (Honda) today announced it has decided to introduce the UNI-ONE hands-free personal mobility device to market and will begin sales to corporate customers in Japan on September 24, 2025.Honda positions UNI-ONE as a “mobility device to be used at destinations” after people arrive by car or another means of transportation. This envisions various use cases, including moving customers around designated areas within certain facilities, or to support diverse individuals, including seniors, to enhance performance and increase productivity in offices and other workplaces.The UNI-ONE will reduce the physical burden people experience on their legs and lower back while walking around, which will encourage more people who have been giving up on opportunities for an outing due to a concern about the physical burden. By commercializing UNI-ONE, Honda will strive to contribute to the “joy and freedom of mobility” for more people. UNI-ONEBy leveraging technologies amassed through its research on robotics, including ASIMO, a humanoid robot, Honda created UNI-ONE as a personal mobility device the user can steer simply by shifting body weight while sitting and keeping both hands free to move naturally in all directions as if they were walking. UNI-ONE was designed to be easy to use for people of all ages, from young children to the elderly, without requiring complex operation.Honda has continued to develop personal mobility devices designed to work in harmony with people, such as U3-X (introduced in 2009) and UNI-CUB (introduced in 2012). As a successor model featuring further advanced technologies, UNI-ONE was introduced for the first time at the International Robot Exhibition 2022 (iREX 2022) and has since been well received by visitors of various exhibitions and test-ride events.Since 2023, Honda has been working with some customers to conduct pre-launch paid trials of the UNI-ONE while making progress in initiatives toward mass production and commercialization. Since it obtained type certification as a “small mobility vehicle,*1” which can be used legally on public roads*2, the UNI-ONE has further expanded its scope of applications.*1 A vehicle is identified as a “small mobility vehicle” and considered equivalent to a pedestrian when it fulfills the following requirements:1) Vehicle dimensions must be below the following measurements:a) Length: 120cmb) Width: 70cmc) Height: 120cm2) Vehicle structure must fulfill the following conditions:a) Use an electric motor as the prime mover.b) Maximum speed must not exceed 6km/h.3) The vehicle must not have any sharp protrusions that could pose a risk of causing harm to pedestrians.*2 Certification of the previous version and the all-new version of UNI-ONE was obtained on January 30 and July 10, 2025, respectively.Intended use cases for UNI-ONEHonda is striving to support people to make their daily lives more enjoyable and comfortable by offering UNI-ONE to be used for various purposes: including reducing the physical burden on users while moving them around designated areas within certain facilities; or reducing the workload of people while they are in an office or other workplaces.Moving around inside a facility:Even if there are comfortable means of transportation to the destination, having to walk a long distance/time at the destination can be a burden, causing some people to give up their opportunity for an outing. UNI-ONE can address such issues and encourage more people to enjoy their outings. Reducing workload at a workplace:Leveraging its unique feature — to enable users to move around as if they are walking while keeping both hands free — UNI-ONE can contribute to productivity improvement and/or a reduction of the workload for people working in the field of office/administration. In addition, the utilization of UNI-ONE can support a diverse workforce, including those who may have difficulty walking, to play active roles in their workplaces. Examples of facilities suitable for the intended use of UNI-ONE1) Theme parks, tourist destinations, parks2) Airports, commercial facilities, museums3) Offices, medical facilities4) Smart cities, station areas5) Outlet malls, shopping malls6) Exhibition halls, warehousesUNI-ONE sales strategyHonda will begin sales of the UNI-ONE to corporate customers in Japan in the form of a “service contract” that packages the UNI-ONE body, swappable battery, maintenance and insurance services. All sales will be conducted through the official UNI-ONE website.Official UNI-ONE websiteURL: https://www.honda.co.jp/UNI-ONE/ (Japanese)Product information, case studies of UNI-ONE utilization and information on test-ride events open to the public are also available on this website. Planned sales volumeLimited to 1,000 units (in a 5-year period until 2023)UNI-ONE “service contract” package- 1 UNI-ONE device- 2 swappable batteries- 1 battery charger- Regular inspection- On-site repair service- Call center support- Insurance- UNI-ONE operation management appMonthly fee per unit (including taxes) Number of units under contractLess than 10 unitsMore than 10 unitsContract term3 years120,000 yen100,000 yen6 years90,000 yen80,000 yenFor use at limited-time events and other special occasions, Honda will offer a short-term rental service, available starting from one day. The package includes one unit of UNI-ONE, two swappable batteries, one charger and insurance for the daily fee of 55,000 yen (including taxes) per unit. Example of a facility which will introduce UNI-ONE for customer use After the start of sales, UNI-ONE will be available for customer use at the Sanrio Character Park “Harmonyland” starting on Sunday, October 19, 2025.Harmonyland is an outdoor theme park set in the natural landscape of Hiji-machi, Hayami-gun, Oita Prefecture, Japan. The park welcomes visitors of all ages with the wish that all visitors, including those who are concerned about walking a long time within the park — such as multi-generation families with small children, the elderly, and people with disabilities — will enjoy the park with their friends and families without facing the burden of walking. The utilization of UNI-ONE will contribute to the realization of this wish and become a step toward addressing the challenge that people with disabilities often face related to their mobility and recreational activities. For this reason, Harmonyland and Honda came to an agreement to introduce UNI-ONE.About the Sanrio Character Park “Harmonyland”Official website: https://www.harmonyland.jp/Operating company: Sanrio Entertainment Co., Ltd.Location address: 5933 Fujiwara, Hiji-machi, Hayami-gun, Oita Prefecture, Japan  Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

Perspective of O Mon 4 Thermal Power Plant project (Photo: Petrovietnam)Singapore, September 8, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Power, a power solutions brand of Mitsubishi Heavy Industries, Ltd. (MHI), today announced that it has been awarded a contract in cooperation with Doosan Enerbility Co, to supply two advanced M701JAC gas turbines and auxiliary equipment for the O Mon 4 Gas Turbine Combined Cycle (GTCC) Power Plant. The agreement was signed in August 2025.The O Mon 4 plant, with a designed capacity of 1,155MW, is developed by the Vietnam National Industry-Energy Group (Petrovietnam), with the engineering, procurement and construction (EPC) contract awarded to a consortium of Doosan Enerbility of South Korea and Vietnam's Power Engineering Consulting Joint Stock Company 2 (PECC2). As the first deployment in Vietnam, Mitsubishi Power will supply the two JAC gas turbines, which are recognized as the world's most efficient large-frame turbines, with more than 64% combined cycle efficiency and proven reliability through 3 million operational hours.The groundbreaking ceremony for O Mon 4 took place in late August in Can Tho, South Vietnam, marking the start of construction, and the plant is scheduled for completion in 2028.O Mon 4 will provide stable electricity for the Mekong Delta, boosting Petrovietnam's installed capacity to more than 9,300MW, equivalent to about 10% of Vietnam's national power system. The project is part of the Block B - O Mon gas-to-power project chain, a national priority designed to strengthen Vietnam's energy security and accelerate the country's energy transition.Akihiro Ondo, CEO and Managing Director of Mitsubishi Power Asia Pacific Pte. Ltd., said, "The O Mon 4 project marks a milestone in Vietnam's energy journey, and we are honored to contribute our state-of-the-art JAC gas turbines to this key power plant. Building on our proven track record across Asia, we are committed to delivering world-class reliability and performance for O Mon 4, working together with our partners."With O Mon 4, Mitsubishi Power strengthens its support for Vietnam's Power Development Plan VIII (PDP8), which calls for diversifying the energy mix, reducing coal dependency, and expanding natural gas and renewable energy. The project also contributes to Vietnam's national target of achieving net zero emissions by 2050.Mitsubishi Power remains committed to advancing its industry-leading gas turbine technologies to deliver reliable electricity, strengthen national energy systems, and support sustainable economic growth across Vietnam and Asia Pacific.   Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com

Kawasaki, Japan, September 8, 2025 - (JCN Newswire via SeaPRwire.com) - Fujitsu today announced the development of a new reconstruction technology for generative AI. The new technology, positioned as a core component of the Fujitsu Kozuchi AI service, will strengthen the Fujitsu Takane LLM by enabling the creation of lightweight, power-efficient AI models.Fujitsu’s new reconstruction technology is built upon two core advancements:Quantization: A technique that significantly compresses information stored in the connections between neurons that forms the basis of an AI model’s "thought" processSpecialized AI distillation: A world-first (1) method which simultaneously achieves both light weighting and accuracy exceeding that of the original AI modelApplying 1-bit quantization technology to Takane has enabled a 94% reduction in memory consumption. This advancement has achieved the world's highest accuracy retention rate of 89% (2) compared to the unquantized model, along with a 3x increase in inference speed. This significantly surpasses the accuracy retention rate of less than 20% typically achieved by conventional mainstream quantization methods like GPTQ. This breakthrough enables large generative AI models that previously required four high-end GPUs to run efficiently on a single low-end GPU.This unprecedented light weighting capability will enable the deployment of agentic AI on edge devices such as smartphones and factory machinery. This will lead to improved real-time responsiveness, enhanced data security, and a radical reduction in power consumption for AI operations, contributing to a sustainable AI society.Fujitsu plans to sequentially offer customers globally trial environments for Takane with the applied quantization technology starting in the second half of fiscal year 2025. Furthermore, Fujitsu will progressively release models of Cohere's research open-weight Command A quantized using this technology, available via Hugging Face (3) starting todayMoving forward, Fujitsu will continue to advance research and development that significantly improves the capabilities of generative AI while ensuring its reliability, aiming to solve more complex challenges faced by customers and society, and to open new possibilities for generative AI utilization.Technology details Many tasks performed by AI agents require only a fraction of the general capabilities of an LLM. The newly developed generative AI reconstruction technology is inspired by the human brain's ability to reconstruct itself, including by reorganizing neural circuits and specializing in specific skills in response to learning, experience, and environmental changes. It efficiently extracts only the knowledge necessary for specific tasks from a massive model with general knowledge, creating a specialized AI model that is lightweight, highly efficient, and reliable. This is achieved through the following two core technologies:1. Quantization technology for streamlining AI “thought” and reducing power consumption:- Parameter compression:* Technology compresses generative AI parameter information, reducing model size and power consumption, and accelerating performance- Quantization error solution:* Previous challenge: exponential quantization error accumulation in multi-layered neural networks (e.g., LLMs)* Fujitsu's solution: technology for quantization error propagation, a new quantization algorithm* Technology for quantization error propagation prevents error growth through cross-layer error propagation, based on theoretical insights- 1-Bit quantization achievement:* 1-bit LLM quantization achieved via Fujitsu's proprietary, world-leading optimization algorithm for large-scale problems2. Specialized distillation for condensing expertise and improving accuracy:- Brain-inspired optimization:* AI model structure optimization, mirroring brain processes of knowledge strengthening and memory organization- Model generation & selection:* Foundational AI model modification: pruning (unnecessary knowledge removal), transformer block additions (new capability impartation)* Diverse candidate model generation* Optimal model selection: Neural Architecture Search (NAS) with Fujitsu's proxy technology, balancing customer requirements (GPU resources, speed) and accuracy- Knowledge distillation:* Knowledge transfer from teacher models (e.g., Takane) into the selected structural model- Beyond compression:* Model compression with enhanced specialized task accuracy, surpassing foundational generative AI model performance- Demonstrated results (sales negotiation prediction):* Text QA task (sales negotiation outcome prediction, Fujitsu CRM data):  - 11x inference speed increase  - 43% accuracy improvement* Student model (1/100th parameter size) achieved higher accuracy than teacher model* 70% reduction in GPU memory and operational costs* Enhanced sales negotiation outcome prediction reliability- Demonstrated results (image recognition):* 10% improvement in unseen object detection accuracy (4) over existing distillation techniques* Significant breakthrough: over three times the accuracy improvement in this domain over two yearsFor more details, please visit: https://global.fujitsu/-/media/Project/Fujitsu/Fujitsu-HQ/pr/news/2025/09/08-01-en.pdfFuture plansMoving forward, Fujitsu will further enhance Takane leveraging this technology, empowering customer business transformations. Future plans include lightweight, specialized Takane-derived agentic AI for finance, manufacturing, healthcare, and retail. Further technology advancements aim for up to 1/1000 model memory reduction with maintained accuracy, enabling ubiquitous high-precision, high-speed generative AI. Ultimately, specialized Takane models will evolve into advanced AI agent architectures for deeper world understanding and autonomous complex problem-solving.About FujitsuFujitsu’s purpose is to make the world more sustainable by building trust in society through innovation. As the digital transformation partner of choice for customers around the globe, our 113,000 employees work to resolve some of the greatest challenges facing humanity. Our range of services and solutions draw on five key technologies: AI, Computing, Networks, Data & Security, and Converging Technologies, which we bring together to deliver sustainability transformation. Fujitsu Limited (TSE:6702) reported consolidated revenues of 3.6 trillion yen (US$23 billion) for the fiscal year ended March 31, 2025 and remains the top digital services company in Japan by market share. Find out more: global.fujitsuPress ContactsFujitsu LimitedPublic and Investor Relations DivisionInquiries  Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com