NEW YORK, Oct 31, 2025 - (ACN Newswire via SeaPRwire.com) - TruMerit President and CEO Peter Preziosi has been elected President of the Conference of Non-Governmental Organizations in Consultative Relationship with the United Nations, also known as CoNGO.CoNGO | TruMeritConference of Non-Governmental Organizations in Consultative Relationship with the United Nations, also known as CoNGO and TruMeritCoNGO is an international non-governmental organization founded in 1948 that relates to the United Nations through its General Consultative Status granted by the United Nations Economic and Social Council (ECOSOC). It has 525 member organizations from around the world and 106 associate members.Dr. Preziosi was elected to serve for the 2025-29 term this week at the 28th CoNGO General Assembly, which took place in New York with the virtual participation of organizations from around the world. He succeeds the Rev. Dr. Liberato C. Bautista, the main representative to the UN for the General Board of Church and Society of The United Methodist Church, who has served as CoNGO's President since 2017 and also held the post from 2007 to 2011.TruMerit has been a member of CoNGO since 2018 and is active in the organization's affairs, having served as the organization's Secretary to the CoNGO Board and as chair of its Membership Committee.Dr. Preziosi is the first Registered Nurse to serve as CoNGO President. He is a nonprofit executive who since early 2023 has led TruMerit, formerly known as CGFNS International, a health workforce development organization committed to advancing the ethical mobility and professional growth of health workers worldwide. Previously, he was employed by the World Health Organization to help establish its technology-driven global learning center, the WHO Academy.Dr. Bautista, the former President of CoNGO, extended his warm congratulations to Dr. Preziosi on his election. "His experience at TruMerit and at WHO, coupled with his profound dedication to multilateralism and his engagement with civil society, provide a basis for optimism regarding CoNGO's future. In an era where the voice and influence of civil society are of paramount importance in shaping a shared future that upholds human dignity and rights, as well as planetary sustainability, Dr. Preziosi's leadership is expected to enhance CoNGO's role as a pivotal supporter and advocate for democratic and equitable participation within the United Nations and beyond," he stated."CoNGO has long been a vital convener of NGOs, a bridge between civil society and an advocate for their engagement at the United Nations, as well as a steadfast champion of inclusive multilateralism - a concept that, unfortunately, is increasingly under attack," said Preziosi."In response, let us assert civil society participation at the United Nations not as a plea, but as a principle - one that is essential to legitimate, effective, and ethical multilateralism, and thereby is critical to the attainment of the Sustainable Development Goals and adherence to the rule of law," he said.About CoNGO (Conference of Non-Governmental Organizations in Consultative Relationship with the United Nations)The Conference of Non-Governmental Organizations in Consultative Relationship with the United Nations (CoNGO) is an independent, international membership association founded in 1948, the year of the Universal Declaration of Human Rights. As a non-governmental organization (NGO) in general consultative status with the UN Economic and Social Council, our work relates to the entire United Nations System: the Secretariat, Agencies, Treaty Bodies, Regional Commissions, Institutes, Summits and World Conferences.CoNGO wholeheartedly endorses the goals and values enshrined in the United Nations Charter and is a strong advocate for multilateralism to resolve global political, environmental, health, and other threats. Close to 30 CoNGO Substantive Committees (called NGO Committees) related to CoNGO in New York, Geneva, Vienna, and regions worldwide demonstrate our commitment to supporting the mission of the United Nations, systemwide. CoNGO has a membership of diverse NGOs working in consultation with the United Nations, in collaboration with each other, and in cooperation with other like-minded stakeholders. ngocongo.orgAbout TruMeritTruMerit is a worldwide leader in healthcare workforce development. Formerly known as CGFNS International, the organization has a nearly 50-year history supporting the career mobility of nurses and other healthcare workers - and those who license and hire them - by validating their education, skills, and experience as they seek authorization to practice in the United States and other countries. As TruMerit, this mission has been expanded to building workforce capacity that meets the needs of people in a rapidly evolving global health landscape. Through its Global Health Workforce Development Institute, the organization is advancing evidence-based research, thought leadership, and advocacy in support of healthcare workforce development solutions, including globally recognized practice standards and certifications that will enhance career pathways for healthcare workers. www.trumerit.orgContact InformationDavid St. Johndstjohn@trumerit.orgSOURCE: TruMerit Copyright 2025 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com
(SeaPRwire) - Microsoft (NASDAQ:MSFT) 最近发布了其季度财报，展示了令人印象深刻的收入数据，超出了华尔街的预期。尽管财务表现强劲，该公司的股票却出人意料地下跌，促使分析师重新评估他们目前的评级和预测。
投资者对市场的反应感到惊讶，因为财报显示营收和利润率都有显著增长。分析师将股价下跌归因于多种因素，包括市场波动和更广泛的经济担忧，这些因素似乎盖过了该公司积极的财务业绩。
Microsoft 的云计算部门 Azure 持续展现强劲增长，为公司整体收入做出了显著贡献。该部门的表现被视为 Microsoft 未来增长的关键驱动力，许多分析师对其长期潜力持积极看法。
尽管市场最初反应不佳，一些分析师正在考虑上调对 Microsoft 的评级，理由是该公司在人工智能和云技术方面的战略投资是持续增长的有希望的指标。这些领域有望在塑造公司在科技行业的竞争优势方面发挥关键作用。
Microsoft 股价的近期下跌可能为投资者提供一个买入机会，他们相信公司的长期前景。然而，这也凸显了股市固有的波动性以及可能影响投资者情绪的复杂因素。
随着 Microsoft 不断创新和拓展其产品线，公司仍处于有利地位，可以抓住科技行业的新兴趋势。最近的财报证明了其在快速变化的市场环境中的韧性和适应性。
总之，尽管市场对 Microsoft 财报的即时反应不如预期，但该公司强劲的财务表现和战略举措预示着光明的未来。投资者和分析师都将在未来几个月密切关注 Microsoft 的进展，因为它力求保持其在全球科技市场中的领导者地位。
脚注： 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。
分类: 头条新闻,日常新闻
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尽管财报积极，Microsoft 的股价反应仍令许多分析师感到意外。.
该公司的云计算部门仍是主要增长动力，影响着分析师的评级。.
On October 28th, the press conference for the "2025 Consumer Electronics Innovation Conference (CEIC 2025)" was held in Shenzhen, China. With the theme of "New Electronics · New Experiences · New Consumption", this conference is hosted by the Hetao "6+1" International Organization Headquaters and undertaken by the International Economic and Center For International Economic and Technological Cooperation Ministry of Industry and Information Technology. It will take place from November 6th to 8th in Hall 2 of Shenzhen Convention and Exhibition Center (Futian), Shenzhen, China. Guided by the mission of "defining the new trend of global consumer electronics", the conference will gather nearly 300 technology enterprises from 20 countries and regions around the world, allowing audiences to have an up-close experience of the future life.
Over 2,000 Innovative Technology Products to Be Showcased, with Many Making Global Debuts
This Consumer Electronics Innovation Conference (https://www.ceic.net) will focus on displaying a large number of smart products and experiences based on world-leading technologies such as HarmonyOS, SparkLink, and Audio & HDR Vivid, building a complete chain of "underlying core technologies - innovative products - unforgettable experiences". More than 2,000 innovative technology products will be showcased in a concentrated manner.
1.The global debut exhibition of the full range of HarmonyOS 6 products will cover 5 categories of terminal devices, including HarmonyOS TVs, HarmonyOS computers, tablets, mobile phones, and wearable devices.
2.The 110-inch large-screen Mate TV will make its global launch, bringing on-site IMAX giant screen viewing experience and a brand-new floating touch interaction.
3.The realistic experience debut of the new-generation smart cockpit will demonstrate vehicle-home smart connection; the cockpit and whole-house intelligence will be transformed into a cross-space mobile butler intelligent entity, creating a new experience of smart cockpit and smart home.
4.The on-site debut exhibition of naked-eye holographic spatial VR equipment will showcase its transformation into desktop/vehicle-mounted aerial imaging equipment, portable giant screen projection equipment, and light field screen equipment, allowing people to experience the future personal visual experience in advance.
5.Leading intelligent sound source localization + deep noise reduction technology: the accuracy of sound source direction reaches within 1 degree, and the noise reduction performance has achieved generational improvement. This technology equips robots with "sensitive hearing", enabling them to accurately identify the location of sound source incidents and intelligently handle various events.
Yang Tao, Deputy Director of the CEIC Organizing Committee and Secretary-General of WAA, introduced at the press conference that this exhibition will cover an area of 15,000 square meters, focusing on five innovative fields: smart terminals, smart cars, smart homes, digital health, and new technology chips. Exhibitors include not only domestic and foreign technology enterprises such as China Media Group, China Mobile, Huawei, BYD, Honor, NIO, XPeng, HiSilicon, EHang Intelligent, ICkey, Shanghai Ningyao, Samsung, DeKera, Toshiba, Dassault, TÜV, and Azapa, but also characteristic exhibition areas such as Shenzhen Huaqiang North Street (China), University Innovation Zone, Developer Activity Zone, and six international industry and standards organizations. These areas will comprehensively and vividly present the latest achievements and cutting-edge trends of the consumer electronics industry.
"Wisdom Collision Platform" Builds an All-Round Connection Bridge
This conference will set up 3 main forums and 16 sub-forums, focusing on the five core fields and conducting in-depth discussions on full-chain innovation from the R&D of underlying "core technologies" to industrial practice.
More than 300 entrepreneurs, scientists, and industry leaders from enterprises, academic circles, and research institutions will gather together to share cutting-edge insights in more than 50 special meetings. The discussions will cover not only the trend prediction of AI empowering consumer electronics, but also the in-depth interpretation of cross-scenario interconnection standards, as well as the review of practical experience of innovative enterprises. This will bring the most cutting-edge ideological collision and in-depth communication to the consumer electronics industry.
Meanwhile, the conference will also hold an "Innovation Capital Forum", building a connection bridge for technology, industry, and capital. More than ten well-known capital institutions will connect with high-growth projects on-site, building a "capital bridge" for innovative technologies and products to accelerate their marketing process.
Adding "Life Warmth" to Technology: Wonderful Conference Activities Stimulate the Vitality of the Innovation Ecosystem
When the thousand-year-old traditional Chinese music meets future technology, a fantastic journey of "Chinese traditional style × Technology × Music" is about to start in Shenzhen, China. During the conference, the Audio Vivid Music Festival will also be held, gathering new talents in traditional Chinese music and pioneers of Guochao (Chinese trend) to present a cross-border feast from elegant solos to exciting ensembles. Audio Vivid, the world's first AI audio coding standard, will serve as the exclusive sound guide, enabling each note to be accurately positioned in 3D space. Being in the scene, it feels like musical instruments are whispering in the ear and melodies are hovering above the head, unlocking the ultimate auditory experience of "being there" with sound.
The National Finals of the 2nd " SparkLink Cup" Application Challenge will also be grandly held on-site during the conference. Focusing on fields such as smart home, smart terminals, and AI robots, the competition aims to explore and cultivate young innovative forces based on the new short-range technology of "SparkLink". Participants will utilize the low-latency and high-reliability characteristics of "SparkLink" to demonstrate their unique advantages in accurate device collaboration and smooth interaction, injecting core driving force into the developer ecosystem.
Focus on New Trends and Explore a New Future in Shenzhen, China
As an innovation highland for the global consumer electronics industry, Shenzhen, China is deeply integrated into the global consumer electronics industry chain and supply chain system. Relying on its solid manufacturing foundation, dynamic innovation ecosystem, and efficient and agile supply chain system, Shenzhen is constantly expanding the breadth and depth of "Created in Shenzhen".
In Shenzhen, from smart phones to smart wearables, and from smart imaging to smart homes, large, medium, and small enterprises work together for common progress and thrive in a "hundred flowers blooming" pattern. The city boasts strong industrial strength: in 2024, the added value of Shenzhen's smart terminal industry cluster exceeded 200 billion yuan, and the output of smart phones accounted for more than one-fifth of the national total. In terms of product innovation, 31 products from Shenzhen were selected into the 2025 Best Inventions list released by Time magazine, accounting for more than 70% of Chinese products on the list; these products include 3D printing equipment, batteries, cameras, mobile phones, headphones, and AR glasses. With a complete industrial chain, Shenzhen has basically formed a full consumer electronics industrial chain ecosystem covering R&D and design, key components, high-end manufacturing, marketing, and brand services.
In March this year, Shenzhen took the lead in issuing the Shenzhen Action Plan for Accelerating the Development of Artificial Intelligence Terminal Industry (2025-2026), which provides precise support for AI technology research, platform construction, product promotion, standard formulation, and ecosystem cultivation. The city has also established a 5 billion yuan AI terminal fund and a 1 billion yuan network, communication, and smart terminal fund, with a focus on investing in the consumer electronics and network communication industry chains.
At the same time, Shenzhen and Dongguan (China) have been approved to jointly build a National Artificial Intelligence Application Pilot Test Base (mobile terminal direction in the consumer field). The base will focus on the scenarios of "AI + Smart Terminals" and "AI + Smart Manufacturing", and build five empowerment centers, including chip application development, chip ecosystem adaptation, operating system adaptation, industrial intelligent entity innovation, and pilot test verification. This will help enterprises achieve digital and intelligent transformation in the AI era.
Organizing Committee of 2025 Consumer Electronics Innovation Conference (CEIC 2025)
Address: Shenzhen-Hong Kong International Science and Technology Park, Shenzhen City, China
Contact Phone: +86 18926418506
Contact Person: Ms. Zhao
Email: ceic@cietc.org.cn
Website: www.ceic.net
Ammonia Cracking Plant (3D Rendering)TOKYO, October 30, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries, Ltd. (MHI) and NIPPON SHOKUBAI CO., LTD. (Nippon Shokubai) have received approval for their jointly submitted proposal to Japan's New Energy and Industrial Technology Development Organization (NEDO) for its "Development of Technologies for Building a Competitive Hydrogen Supply Chain" project.The selected project aims to develop technology for the construction of a hydrogen supply chain using ammonia as a hydrogen carrier (hydrogen storage and transport medium), promoting development of medium-scale, decentralized ammonia cracking technology near hydrogen demand sites. The project advances ammonia cracking technology using steam and exhaust gases, employing an independently developed, low-temperature, highly active and highly durable ammonia cracking catalyst without the use of noble metals typically used in conventional low-temperature active catalysts. This innovative technology will be used to verify challenges toward practical application.Following the project selection, the two companies will conduct the following activities during the project period through fiscal 2027, with long-term testing in mind, using a commercial-scale demonstration plant. MHI will leverage its extensive experience in ammonia plant construction and its knowledge of ammonia handling to carry out the basic design (Front End Engineering Design: FEED) of the demonstration plant. MHI will finalize the demonstration plant specifications aiming to resolve technical challenges necessary for commercialization, with support from Hokkaido Electric Power Co., Inc. (HEPCO). Nippon Shokubai will promote the development of elemental technologies focused on verifying the durability of ammonia cracking catalysts, utilizing its abundant experience and expertise in catalyst development and practical application, including process catalysts such as acrylic acid catalysts and environmental catalysts for automotive and exhaust gas treatment.MHI and Nippon Shokubai will promote the development of ammonia cracking systems that contribute to building hydrogen and ammonia supply chains, aiming for early establishment and social implementation of decarbonization technologies, and contributing to the realization of a sustainable carbon-neutral society.HEPCO, aiming to achieve carbon neutrality in Hokkaido by 2050 across the entire energy sector, is expanding the introduction of renewable energy and decarbonizing power sources, while promoting initiatives related to ammonia, hydrogen, and carbon capture utilization and storage (CCUS) in the Tomakomai region and other areas of Hokkaido.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
TOKYO, October 30, 2025 - (JCN Newswire via SeaPRwire.com) - NEC Corporation (NEC; TSE: 6701), a leading global IT and network transformation services provider, and e&, a global technology group, have announced a strategic partnership. The two organizations have signed a Memorandum of Understanding (MoU) establishing a framework for joint sustainability initiatives focused on reducing environmental impact, advancing social inclusion, and creating long-term economic value.The MoU was signed by NEC’s GCC branch and e&, aligning the two companies on collaborative programs that advance responsible growth and underpin transparent sustainability governance.Operating in 38 countries across the Middle East, Asia, Africa, and Europe, e& is focused on driving sustainable growth, digital empowerment, and innovation. With a strong commitment to Environmental, Social, and Governance (ESG) principles, e& continuously seeks partnerships that amplify its positive environmental and social impact.NEC, sharing this vision, integrates sustainability into its operations and global supply chain, prioritizing environmental harmony and responsible growth. This shared commitment forms the foundation of their new strategic collaboration.Under the MoU, the two companies will explore joint initiatives to reduce their environmental footprint, develop low-carbon and energy-efficient solutions, and promote circular economy practices. The collaboration also covers areas such as renewable integration, resource optimization, and transparent sustainability governance—all designed to accelerate the transition toward a more sustainable digital future. This MoU with NEC is an initiative that stems from Project Life which is a transformative initiative launched by e& Group Procurement to drive its Responsible Sourcing Strategy and align with the e& group-wide sustainability vision of 2030, further reinforcing e&’s commitment to sustainable and responsible sourcing."I firmly believe that strong partner relationships are the cornerstone of our success. These partnerships are not only instrumental in driving innovation, efficiency, and mutual growth but also play a pivotal role in fostering sustainable practices that benefit our communities and the environment. Together, we are committed to building a future where collaboration, trust, and sustainability converge to create shared achievements and long-term value for all stakeholders."Saeed Al Zarooni - Group Chief Procurement Officer of e& Group"Through this MoU with NEC, we’re aligning delivery with our Climate Transition Plan, ‘Ambition to Action’, which outlines our pathway to net zero. This partnership reflects our shared ambition to accelerate sustainable innovation and deliver meaningful impact. As long-term trusted partners, we are confident that our collaboration with NEC will create lasting value, support environmental goals, and drive inclusive digital transformation for the benefit of our communities and the planet. By combining technology with clear accountability, we aim to help industries transition to a greener, more inclusive digital future."- Andrew Dunnett, Group Senior Vice President of Sustainability, e&"We are proud to collaborate with e& through this MoU to support both business growth and sustainability ambitions. NEC is committed to delivering innovative, energy-efficient solutions that help drive environmental progress and operational excellence through technology and shared values."- Masayuki Kayahara, Corporate SVP, Global Network Division, NEC CorporationTogether, NEC and e& aim to set a benchmark for sustainable innovation, fostering a legacy of environmental stewardship and positive societal impact.About NEC CorporationNEC Corporation has established itself as a leader in the integration of IT and network technologies while promoting the brand statement of "Orchestrating a brighter world." NEC enables businesses and communities to adapt to rapid changes taking place in both society and the market as it provides for the social values of safety, security, fairness and efficiency to promote a more sustainable world where everyone has the chance to reach their full potential. For more information, visit NEC at https://www.nec.com or NEC’s Network Solutions at https://www.nec.com/en/global/solutions/5g/index.html.About e&e& is a global technology group committed to advancing the digital future across markets in the Middle East, Asia, Africa and Europe. With the group's financial performance in 2024 showing a consolidated revenue of AED 59.2 billion and a net profit of AED 10.8 billion, e& continues to maintain its position as a financial powerhouse, reflected by its strong credit rating and solid balance sheet.Founded in Abu Dhabi over 48 years ago, e& has evolved from a telecom pioneer into a technology group. Its footprint now spans 38 countries, offering a comprehensive portfolio of innovative digital services ranging from advanced connectivity, entertainment, streaming and financial services to AI-powered solutions, cloud computing, ICT, cybersecurity and IoT platforms.The Group is structured around five core business pillars: e& UAE, e& international, e& life, e& enterprise and e& capital, each catering to distinct customer and market needs. These pillars empower e& to lead in various sectors, from telecom and digital lifestyle to enterprise services and venture investments. The ongoing strategic investments in AI, IoT, 5G and cloud services reinforce its leadership in the global technology landscape, driving the future of smart connectivity and innovation.Driven by innovation, sustainability and a commitment to digital empowerment, e& is set on creating a smarter, more connected future for individuals, businesses and communities.To learn more about e&, visit eand.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
Auckland, New Zealand – October 30, 2025 – (SeaPRwire) – At the inaugural European Union – New Zealand Business Summit, Decent Cybersecurity represented Europe’s growing strength in digital and defence technologies. The company’s Founder and CEO, Matej Michalko, joined industry leaders to discuss innovation partnerships, cybersecurity resilience, and post-quantum readiness across trans-Pacific markets. The event gathered over 400 participants from business, technology, and research communities, underscoring a shared commitment to building secure and sustainable digital infrastructure between Europe and New Zealand.
Hosted by Hon Todd McClay, New Zealand’s Minister for Trade & Investment, in partnership with Team Europe (the Ambassadors of the EU and its Member States), the Summit celebrated the strong growth of trans-Pacific cooperation. Since the EU–NZ Free Trade Agreement entered into force in 2024, two-way trade has already risen by NZ $2 billion, reaching NZ $21.6 billion in 2025.
The event was officially opened by Prime Minister Christopher Luxon, who described the EU as “an innovation partner” and emphasised the shared values and strategic alignment between Europe and New Zealand in advancing trade, defence, and technology.
A Platform for Global Partnerships and Digital Innovation
Commissioner Šefčovič, a native of Slovakia, delivered a keynote address outlining Europe’s vision for resilient supply chains, strategic autonomy, and secure digital transition. Later in the day, the “Quickfire with Central and Eastern Europe” session showcased innovation leaders from across the region.
Representing European Union and its member country Slovakia, Matej Michalko presented on the country’s growing role in post-quantum cybersecurity, AI for defence systems, and trusted blockchain infrastructure — areas where Decent Cybersecurity is establishing Europe-wide leadership.
“It was an honour to represent European Union and Slovakia alongside Commissioner Šefčovič and to demonstrate how our country is contributing to Europe’s digital and defence sovereignty,” said Matej Michalko, CEO of Decent Cybersecurity. “The EU–New Zealand partnership opens new doors for innovation, technology exchange, and secure infrastructure development that transcend continents.”
Shared Vision for Innovation and Security
The Summit agenda featured strategic panels on clean tech, AI, bioeconomy, and aerospace & defence, with global leaders from Airbus, Rocket Lab, OHB, and Maersk. It culminated with a joint address by Commissioner Šefčovič and Minister McClay, setting out a shared vision for deeper economic and technological integration between Europe and New Zealand — an effort strongly endorsed by Prime Minister Luxon in his opening remarks.
For Decent Cybersecurity, participation in this summit reinforces its mission to connect European post-quantum, blockchain and AI-driven innovation with global partners in the Asia-Pacific region — bridging defence, technology, and critical-infrastructure ecosystems.
About Decent Cybersecurity
Decent Cybersecurity s. r. o. is a European deep-tech company developing post-quantum and blockchain-based cybersecurity solutions for defence and critical infrastructure. Certified by TÜV SÜD (ISO 9001 and ISO 27001) and holding NATO, EU, and national SECRET-level security clearances, the company is a member of European Defence Fund (EDF) projects and a founding member of the Critical Infrastructure Association of Slovak Republic (Asociácia kritickej infraštruktúry SR, AKI SR).
Media contact
Brand: Decent Cybersecurity
Contact: Media team
Email: business@decentcybersecurity.eu
Website: https://decentcybersecurity.eu
Hydrolution EZY SeriesTOKYO, October 30, 2025 - (JCN Newswire via SeaPRwire.com) - Mitsubishi Heavy Industries Thermal Systems, Ltd. (MHI Thermal Systems), a part of Mitsubishi Heavy Industries (MHI) Group, has added two new models to its "Hydrolution EZY" series of air-to-water (ATW) heat pumps for the European market that utilize R290 (propane). This is a natural refrigerant with low environmental impact and high energy efficiency. The new models have capacities of 6kW and 7.1kW and are scheduled for release this winter.ATW heat pumps extract heat from the air to supply cold and hot water for domestic water supply, heating, and cooling, replacing traditional fossil-fueled boilers.The models added to the lineup are monobloc types in which the water heat exchanger is housed in an outdoor unit, with only water piping required. Compared to split-type ATWs, which require the refrigerant pipe connections between an outdoor unit and an indoor unit, installation is easier.The R290 refrigerant used in these models has a very low environmental impact(*1) while retaining high energy efficiency. This is particularly important for the European market, as environmental regulations are tightened.Modifications that allow the use of R290 also enable the units to maintain a flow temperature of 75 in a wide range of environments, from an outside temperature of -25 to 43 meaning the unit can be relied upon for heating and domestic hot water applications even in the coldest regions. These latest models, in addition to high-temperature water-heating capabilities, are silent and easy to install, with only water piping and an electricity supply to the outdoor unit required. When operating at maximum capacity, the 6kW model has a sound pressure level, a measure of noise intensity, of just 34dB(A)(*2). The unit also has a quiet mode for reduced operating noise, providing flexibility to comply with noise regulations in densely populated residential areas.In addition, as a safety measure, the units are equipped with a refrigerant leak detection sensor. In the event of a leak, the unit will stop running, and a fan engaged to dissipate any escaped refrigerant.In order to better integrate into a range of installation environments across Europe, including residential areas, the models have been visually redesigned with an understated, modern appearance. The front of the now all-black unit is fitted with a fan guard accented with a silver vertical line and is designed to make it difficult to see the fan from an oblique direction.By promoting the transition from boiler combustion using fossil fuels that emit high concentrations of CO2, to ATW using electricity, Hydrolution EZY can make a significant contribution to carbon neutrality in European countries, and the achievement of MHI Group's MISSION NET ZERO.In October 2021, MHI Group announced its MISSION NET ZERO declaration to achieve carbon neutrality across the entire corporate group by 2040 by reducing CO2 emissions from its own plants and other production-related facilities, as well as through reductions in the CO2 emissions at customer facilities that use MHI Group products.Going forward, MHI Thermal Systems will continue to develop environmentally friendly technologies and products that take advantage of the breadth of the refrigeration and heating sector, and contribute to carbon neutrality in Europe and countries around the world.(*1) R290 has a global warming potential (GWP) of only 0.02. Global Warming Potential (GWP) is a coefficient expressing the greenhouse effect of a gas relative to carbon dioxide (CO2), which has a fixed GWP of 1.0. The lower the value, the lower the greenhouse effect and the better for the environment. The GWP value of "0.02" is adopted based on the IPCC Sixth Assessment Report.(*2) Value measured at three meters in front of the unit.About MHI GroupMitsubishi Heavy Industries (MHI) Group is one of the world’s leading industrial groups, spanning energy, smart infrastructure, industrial machinery, aerospace and defense. MHI Group combines cutting-edge technology with deep experience to deliver innovative, integrated solutions that help to realize a carbon neutral world, improve the quality of life and ensure a safer world. For more information, please visit www.mhi.com or follow our insights and stories on spectra.mhi.com Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
Auckland, New Zealand, Oct 30, 2025 - (ACN Newswire via SeaPRwire.com) - At the inaugural European Union – New Zealand Business Summit, Decent Cybersecurity represented Europe's growing strength in digital and defence technologies. The company's Founder and CEO, Matej Michalko, joined industry leaders to discuss innovation partnerships, cybersecurity resilience, and post-quantum readiness across trans-Pacific markets. The event gathered over 400 participants from business, technology, and research communities, underscoring a shared commitment to building secure and sustainable digital infrastructure between Europe and New Zealand.Hosted by Hon Todd McClay, New Zealand's Minister for Trade & Investment, in partnership with Team Europe (the Ambassadors of the EU and its Member States), the Summit celebrated the strong growth of trans-Pacific cooperation. Since the EU–NZ Free Trade Agreement entered into force in 2024, two-way trade has already risen by NZ $2 billion, reaching NZ $21.6 billion in 2025.The event was officially opened by Prime Minister Christopher Luxon, who described the EU as "an innovation partner" and emphasised the shared values and strategic alignment between Europe and New Zealand in advancing trade, defence, and technology.A Platform for Global Partnerships and Digital InnovationCommissioner Šefcovic, a native of Slovakia, delivered a keynote address outlining Europe's vision for resilient supply chains, strategic autonomy, and secure digital transition. Later in the day, the "Quickfire with Central and Eastern Europe" session showcased innovation leaders from across the region.Representing European Union and its member country Slovakia, Matej Michalko presented on the country's growing role in post-quantum cybersecurity, AI for defence systems, and trusted blockchain infrastructure — areas where Decent Cybersecurity is establishing Europe-wide leadership."It was an honour to represent European Union and Slovakia alongside Commissioner Šefcovic and to demonstrate how our country is contributing to Europe's digital and defence sovereignty," said Matej Michalko, CEO of Decent Cybersecurity. "The EU–New Zealand partnership opens new doors for innovation, technology exchange, and secure infrastructure development that transcend continents."Shared Vision for Innovation and SecurityThe Summit agenda featured strategic panels on clean tech, AI, bioeconomy, and aerospace & defence, with global leaders from Airbus, Rocket Lab, OHB, and Maersk. It culminated with a joint address by Commissioner Šefcovic and Minister McClay, setting out a shared vision for deeper economic and technological integration between Europe and New Zealand — an effort strongly endorsed by Prime Minister Luxon in his opening remarks.For Decent Cybersecurity, participation in this summit reinforces its mission to connect European post-quantum, blockchain and AI-driven innovation with global partners in the Asia-Pacific region — bridging defence, technology, and critical-infrastructure ecosystems.About Decent CybersecurityDecent Cybersecurity s. r. o. is a European deep-tech company developing post-quantum and blockchain-based cybersecurity solutions for defence and critical infrastructure. Certified by TÜV SÜD (ISO 9001 and ISO 27001) and holding NATO, EU, and national SECRET-level security clearances, the company is a member of European Defence Fund (EDF) projects and a founding member of the Critical Infrastructure Association of Slovak Republic (Asociácia kritickej infraštruktúry SR, AKI SR).Media contactBrand: Decent CybersecurityContact: Media teamWebsite: https://decentcybersecurity.eu Copyright 2025 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com
Zurich and New York, October 30, 2025 - (JCN Newswire via SeaPRwire.com) - Hitachi Energy, a wholly owned subsidiary of Hitachi, Ltd., today announced a strategic partnership with Blackstone Energy Transition Partners (“Blackstone”) to expand and strengthen its Service business, supporting customers in maintaining the reliability and safety of power infrastructure across North America. As part of the partnership, Hitachi Energy will acquire a stake in Shermco – a leading provider of comprehensive maintenance, repair, testing, commissioning, and design services in North America, recently acquired by private equity funds affiliated with Blackstone.The partnership brings together three industry leaders: Hitachi Energy, a global technology leader in electrification; Blackstone, the world’s largest alternative asset manager; and Shermco, a leading provider of electrical services in the U.S. and Canada. Together, they will seek to expand service capacity and capabilities to deliver comprehensive lifecycle support for critical energy infrastructure, from power generation and transmission to data centers and industrial electrification.“Investing in Shermco in partnership with Blackstone enables Hitachi Energy to accelerate our growth and expand service capabilities across North America. Our investment strengthens our service offering as we continue to scale, helping customers maintain and extend the life of existing assets while making the grid stronger, more resilient and fit for the future.”“We’re thrilled to welcome Hitachi Energy as a strategic partner alongside Blackstone,” said Phil Petrocelli, CEO of Shermco. “This investment is a testament to our commitment to serving our customers’ essential power needs and reputation for safety and excellence. With this additional support and resources, we look forward to expanding our footprint and capabilities to continue to accelerate our growth together.”“Hitachi Energy is a global leader across technology and energy with deep digital and operational expertise,” said David Foley, Global Head of Blackstone Energy Transition Partners. “We are excited to partner with Hitachi Energy to build on Shermco's success alongside Phil Petrocelli and its exceptional management team.” JP Munfa and Darius Sepassi, Senior Managing Directors at Blackstone, added, “Hitachi Energy’s investment in Shermco brings together a global technology leader in electrification with one of the leading North American providers of mission-critical maintenance, testing and design services for electrical equipment. We are thrilled to be partnering with Hitachi Energy and look forward to working together to accelerate Shermco’s next phase of growth in an era of rapid electrification and increasing demand.”Hitachi Energy’s $1 billion global investment in ServiceIn addition, Hitachi Energy is investing more than $1 billion USD globally to expand its Service footprint, launching new digital service solutions with HMAX Energy, and growing its workforce — including the development and certification of over 5,000 additional service experts worldwide. “By combining Hitachi Energy’s grid expertise and digital solutions with Shermco’s nationwide field service presence, we will set a new benchmark for electrical infrastructure services – creating the leading service partner in North America driving asset reliability and performance as well as digital innovation for utilities, industries and data centers alike,” said Wolf Mueller, Managing Director of Hitachi Energy’s Service Business.Strengthening Service capabilities for the electricity eraGlobally, power grids are aging, and the experienced workforce is retiring, creating significant challenges. As electrification accelerates across industries, transportation, and digital infrastructure, service is the backbone of grid modernization. Much of today’s grid infrastructure – more than 70 percent of U.S. transmission lines1 – is decades old, nearing or past its intended lifecycle, leading to higher outage risks, cyber vulnerabilities and costly emergency repairs. Service is critical to help data centers, utilities and industries maintain, upgrade, and optimize their infrastructure and increase the reliability, safety, flexibility and sustainability of energy systems.1DOE, What does it take to modernize the U.S.electric grid?(1) Founded in 1974 and headquartered in Texas, Shermco is one of the largest electrical testing organizations accredited by the InterNational Electrical Testing Association (“NETA”), providing comprehensive electrical system maintenance, repair, testing, commissioning and design services, with more than 600 NETA technicians and 200 engineers across 40 service centers in the U.S. and Canada. Shermco provides critical services for data centers, utilities and diversified commercial and industrial end-markets, partnering with customers to enhance the safety, reliability and efficiency of their critical electrical infrastructure, while minimizing downtime and outages.(2) HMAX Energy is Hitachi’s upcoming digitally enabled and AI-powered services offering related to the energy sector. As a key pillar of the company’s Lumada 3.0 strategy, HMAX Energy integrates digital capabilities, domain expertise, service excellence, and installed base intelligence to maximize uptime, safety, efficiency, and asset lifetime. These capabilities will empower customers to shift from reacting to predicting - future-proofing their energy infrastructure.About Hitachi, Ltd.Through its Social Innovation Business (SIB) that brings together IT, OT (Operational Technology) and products, Hitachi contributes to a harmonized society where the environment, wellbeing, and economic growth are in balance. Hitachi operates globally in four sectors – Digital Systems & Services, Energy, Mobility, and Connective Industries – and the Strategic SIB Business Unit for new growth businesses. With Lumada at its core, Hitachi generates value from integrating data, technology and domain knowledge to solve customer and social challenges. Revenues for FY2024 (ended March 31, 2025) totaled 9,783.3 billion yen, with 618 consolidated subsidiaries and approximately 280,000 employees worldwide. Visit us at https://www.hitachi.com.About Hitachi EnergyHitachi Energy is a global technology leader in electrification, powering a sustainable energy future with innovative power grid technologies with digital at the core. Over three billion people depend on our technologies to power their daily lives. With over a century in pioneering mission-critical technologies like high-voltage, transformers, automation, and power electronics, we are addressing the most urgent energy challenge of our time – balancing soaring electricity demand, while decarbonizing the power system. With an unparalleled installed base in over 140 countries, we co-create and build long-term partnerships across the utility, industry, transportation, data centers, and infrastructure sectors. Headquartered in Switzerland, we employ over 50,000 people in 60 countries and generate revenues of around $16 billion USD.https://www.hitachienergy.comhttps://www.linkedin.com/company/hitachienergyhttps://x.com/HitachiEnergyAbout Blackstone Energy Transition PartnersBlackstone Energy Transition Partners is Blackstone’s strategy for control-oriented equity investments in energy-related businesses, a leading energy investor with a successful long-term record, having committed over $27 billion of equity globally across a broad range of sectors within the energy industry. Our investment philosophy is based on backing exceptional management teams with flexible capital to provide solutions that help energy companies grow and improve performance, thereby delivering more reliable, affordable and cleaner energy to meet the needs of the global community. In the process, we build stronger, larger scale enterprises, create jobs and generate lasting value for our investors, employees and all stakeholders. Further information is available at https://www.blackstone.com/our-businesses/blackstone-energy-transition-partners/.About ShermcoHeadquartered in Irving, TX, Shermco provides electrical testing, maintenance, commissioning and repair services to a wide range of utility, industrial, energy and other end markets. With more than 40 locations, Shermco serves a diversified blue-chip client base across North America. The Company is an active participant in NETA (the InterNational Electrical Testing Association), EASA (Electrical Apparatus Service Association), and ACP (American Clean Power Association). For more information, visit www.shermco.com. Copyright 2025 JCN Newswire via SeaPRwire.com. All rights reserved. www.jcnnewswire.com
(SeaPRwire) - Meta Platforms Inc. (NASDAQ:META) 近日公布了其财务指导，重点是增加对人工智能 (AI) 的投资。这一声明并未受到华尔街的欢迎，因为它引发了人们对该公司在不断升级的 AI 相关开支下未来盈利能力的担忧。分析师们对如此巨大的投资能否在短期内产生可观回报表示怀疑。然而，该公司仍持乐观态度，坚称这些支出对于保持其在科技领域的竞争优势至关重要。
这家科技巨头对 AI 的承诺是将其先进技术整合到其产品和服务组合中的一项更广泛战略的一部分。Meta 认为，通过利用 AI，它可以增强用户体验、改善内容审核并推动其平台上的创新。尽管前景光明，但考虑到 AI 开发所需的大量资本，投资者对利润率可能受到的影响持谨慎态度。
历史上，Meta 以其积极的投资策略而闻名，经常将资源投入新兴技术以巩固其市场地位。尽管这种方法此前曾取得成功，但与 AI 相关的高风险导致金融分析师加大了审查力度。随着投资者权衡潜在收益与即时财务负担，该公司的股价出现了波动。
Meta 计划部署 AI 的一个关键领域是广告。通过优化广告投放和定位，AI 有望增加收入来源。然而，这些实施的有效性仍有待观察，任何实现回报的延迟都可能加剧投资者的焦虑。此外，竞争格局正在加剧，其他科技巨头也在争夺 AI 霸主地位。
为应对这些挑战，Meta 概述了几项旨在平衡其 AI 抱负与财政责任的举措。在非核心领域削减成本以及注重效率是该公司降低财务风险战略的一部分。此外，Meta 的领导层强调在沟通其 AI 项目预期成果方面的透明度，旨在让利益相关者对其长期愿景感到放心。
市场对 Meta 的 AI 支出策略的普遍反应反映出一种谨慎的乐观态度。尽管巨大的技术进步潜力得到认可，但围绕即时财务影响的不确定性不容忽视。这种情况凸显了科技公司面临的一个普遍困境：创新需求与管理投资者期望之间的平衡。
随着 Meta 在其 AI 计划上取得进展，未来几个季度将是决定该公司冒险是否会成功 payoff 的关键。成功不仅会验证其战略方向，还会增强人们对其驾驭技术演变复杂性能力的信心。相反，任何挫折都可能促使其重新评估投资重点，并可能影响其在华尔街的地位。
脚注: 本文由第三方内容提供商提供。SeaPRwire (https://www.seaprwire.com/)对此不作任何保证或陈述。
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Meta 的最新财务指导因 AI 支出增加而引发了对未来盈利能力的担忧。
SHENZHEN, Oct 30, 2025 - (ACN Newswire via SeaPRwire.com) - China Medical System Holdings Limited (“CMS”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement of CMS on 22 April 2025 for details) together with its subsidiaries, holds co-development rights (except for atopic dermatitis (AD)) and exclusive commercialization rights for the Class 1 innovative drug anti-IL-4Rα MG-K10 humanized monoclonal antibody injection (“MG-K10” or the “Product”). The New Drug Application (“NDA”) has been accepted by National Medical Products Administration (“NMPA”) on 30 October 2025. The product is intended for the treatment of adult with moderate-to-severe AD whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.MG-K10 (generic name: Comekibart Injection) is an innovative long-acting anti-IL-4Rα humanized monoclonal antibody that simultaneously blocks the signaling of key type 2 inflammatory cytokines IL-4 and IL-13. With a longer half-life, the Product enables a four-week dosing frequency (currently marketed anti-IL-4Rα drugs require biweekly dosing), which is expected to improve patient adherence. MG-K10 is expected to become the world's first long-acting anti-IL-4Rα monoclonal antibody to be launched on the market, and has the potential to become the Best-in-Class (BIC).MG-K10 has achieved positive results in a randomized, double-blind, placebo-controlled Phase III clinical study in adults with moderate-to-severe AD, meeting the primary research endpoint as designed, and at 52 weeks of treatment with MG-K10, proportion of participants with Investigator Global Assessment (IGA) score of 0 or 1, also with an improvement of ≥2 points from baseline is 76.6%; proportion of participants with ≥75% reduction in Eczema Area and Severity Index (EASI 75) from baseline is 94.3 %; proportion of participants with ≥90% reduction in Eczema Area and Severity Index (EASI 90) from baseline is 79.1 %. Regarding safety, most of the Treatment Emergent Adverse Event (TEAE) were Grade 1-2, with no Adverse Event of Special Interest (AESI) or fatal adverse event occurred. The incidence of common adverse reactions (conjunctivitis, injection site reactions, etc.) of drugs with the same target is relatively low for MG-K10.The Product has the potential for the treatment of other type 2 inflammatory diseases, such as asthma, prurigo nodularis, seasonal allergic rhinitis, chronic obstructive pulmonary disease, chronic spontaneous urticaria, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. Among them, asthma, prurigo nodularis and seasonal allergic rhinitis have all entered the phase III clinical trial stage in China.If MG-K10 is approved, it will provide a new, effective, and safe systemic treatment option for 14.5 million patients with moderate-to-severe AD[1]. Furthermore, MG-K10 will generate synergy with Dermavon's ruxolitinib cream (for mild to moderate AD), the oral small molecule TYK2 inhibitor CMS-D001 (for moderate to severe AD), and dermatology-grade skincare products of Heling soothing product series, establishing a comprehensive solution for AD that covers various administration routes (injection, oral, and topical) and addresses multiple needs in “treatment + care”, benefiting a wide range of AD patients. Concurrently, it will further enrich Dermavon's product portfolio in the field of dermatological treatment and reinforce its leading position in skin health sector.On 24 January 2025, CMS through its subsidiaries entered into a Collaboration Agreement (“Agreement”) with Hunan Mabgeek Biotech Co., LTD and its subsidiaries for MG-K10. In accordance with the Agreement and supplementary agreements, CMS has obtained the co-development rights (excluding AD) and exclusive commercialization rights for the Product in Mainland China, Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Region and Singapore; its subsidiary Dermavon has obtained, through its subsidiary, the co-development rights (excluding AD) and exclusive commercialization rights for the Product in the field of dermatological indications in Mainland China.About AD IndicationMG-K10’s first indication, AD, is a chronic inflammatory skin disease accompanied by severe itching. It is the most burdensome non-fatal skin disease worldwide and also a chronic disease with a relatively high prevalence and significant disease burden in China. It is estimated that there are over 54 million AD patients in China in 2024. Based on SCORAD scores, the proportion of moderate to severe AD in China was 27%, which means there are over 14.5 million patients[1]. Due to the limitations in efficacy and safety of traditional systemic therapies for AD, moderate to severe AD patients often experience delays in systemic treatment initiation, poor compliance, and suboptimal disease control, leaving a significant unmet need in clinical practice[2]. MG-K10, with its extended dosing interval of once every four weeks, is expected to improve patient adherence and provide a new, effective, and safe systemic treatment option for patients with moderate-to-severe AD.About CMSCMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/ gastroenterology/ ophthalmology/ skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.Reference:1. China Insights Consultancy. Industry report on global and China Dermatology Treatment and Care Industry2. Chinese Society of Dermatology, China Dermatologist Association. Clinical pathway for the diagnosis and treatment of moderate to severe atopic dermatitis in China (2023): an expert consensus[J]. Chinese Journal of Dermatology, 2023, 56(11): 1000-1007. DOI: 10.35541/cjd.20230247.CMS Disclaimer and Forward-Looking StatementsThis press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.Media ContactBrand: China Medical System Holdings Ltd.Contact: CMS Investor RelationsEmail: ir@cms.net.cnWebsite: https://web.cms.net.cn/en/home/ Copyright 2025 ACN Newswire via SeaPRwire.com. All rights reserved. www.acnnewswire.com
SHENZHEN, CHINA – October 30, 2025 – (SeaPRwire) – China Medical System Holdings Limited (“CMS”) is pleased to announce that its subsidiary, Dermavon Holdings Limited (“Dermavon”, an innovative pharmaceutical company specialized in skin health which is applying for a separate listing on the Main Board of The Stock Exchange of Hong Kong Limited, please refer to the announcement of CMS on 22 April 2025 for details) together with its subsidiaries, holds co-development rights (except for atopic dermatitis (AD)) and exclusive commercialization rights for the Class 1 innovative drug anti-IL-4Rα MG-K10 humanized monoclonal antibody injection (“MG-K10” or the “Product”). The New Drug Application (“NDA”) has been accepted by National Medical Products Administration (“NMPA”) on 30 October 2025. The product is intended for the treatment of adult with moderate-to-severe AD whose disease is not adequately controlled with topical prescription therapies or when those therapies are not advisable.
MG-K10 (generic name: Comekibart Injection) is an innovative long-acting anti-IL-4Rα humanized monoclonal antibody that simultaneously blocks the signaling of key type 2 inflammatory cytokines IL-4 and IL-13. With a longer half-life, the Product enables a four-week dosing frequency (currently marketed anti-IL-4Rα drugs require biweekly dosing), which is expected to improve patient adherence. MG-K10 is expected to become the world’s first long-acting anti-IL-4Rα monoclonal antibody to be launched on the market, and has the potential to become the Best-in-Class (BIC).
MG-K10 has achieved positive results in a randomized, double-blind, placebo-controlled Phase III clinical study in adults with moderate-to-severe AD, meeting the primary research endpoint as designed, and at 52 weeks of treatment with MG-K10, proportion of participants with Investigator Global Assessment (IGA) score of 0 or 1, also with an improvement of ≥2 points from baseline is 76.6%; proportion of participants with ≥75% reduction in Eczema Area and Severity Index (EASI 75) from baseline is 94.3 %; proportion of participants with ≥90% reduction in Eczema Area and Severity Index (EASI 90) from baseline is 79.1 %. Regarding safety, most of the Treatment Emergent Adverse Event (TEAE) were Grade 1-2, with no Adverse Event of Special Interest (AESI) or fatal adverse event occurred. The incidence of common adverse reactions (conjunctivitis, injection site reactions, etc.) of drugs with the same target is relatively low for MG-K10.
The Product has the potential for the treatment of other type 2 inflammatory diseases, such as asthma, prurigo nodularis, seasonal allergic rhinitis, chronic obstructive pulmonary disease, chronic spontaneous urticaria, chronic rhinosinusitis with nasal polyps, and eosinophilic esophagitis. Among them, asthma, prurigo nodularis and seasonal allergic rhinitis have all entered the phase III clinical trial stage in China.
If MG-K10 is approved, it will provide a new, effective, and safe systemic treatment option for 14.5 million patients with moderate-to-severe AD[1]. Furthermore, MG-K10 will generate synergy with Dermavon’s ruxolitinib cream (for mild to moderate AD), the oral small molecule TYK2 inhibitor CMS-D001 (for moderate to severe AD), and dermatology-grade skincare products of Heling soothing product series, establishing a comprehensive solution for AD that covers various administration routes (injection, oral, and topical) and addresses multiple needs in “treatment + care”, benefiting a wide range of AD patients. Concurrently, it will further enrich Dermavon’s product portfolio in the field of dermatological treatment and reinforce its leading position in skin health sector.
On 24 January 2025, CMS through its subsidiaries entered into a Collaboration Agreement (“Agreement”) with Hunan Mabgeek Biotech Co., LTD and its subsidiaries for MG-K10. In accordance with the Agreement and supplementary agreements, CMS has obtained the co-development rights (excluding AD) and exclusive commercialization rights for the Product in Mainland China, Hong Kong Special Administrative Region, Macao Special Administrative Region, Taiwan Region and Singapore; its subsidiary Dermavon has obtained, through its subsidiary, the co-development rights (excluding AD) and exclusive commercialization rights for the Product in the field of dermatological indications in Mainland China.
About AD Indication
MG-K10’s first indication, AD, is a chronic inflammatory skin disease accompanied by severe itching. It is the most burdensome non-fatal skin disease worldwide and also a chronic disease with a relatively high prevalence and significant disease burden in China. It is estimated that there are over 54 million AD patients in China in 2024. Based on SCORAD scores, the proportion of moderate to severe AD in China was 27%, which means there are over 14.5 million patients[1]. Due to the limitations in efficacy and safety of traditional systemic therapies for AD, moderate to severe AD patients often experience delays in systemic treatment initiation, poor compliance, and suboptimal disease control, leaving a significant unmet need in clinical practice[2]. MG-K10, with its extended dosing interval of once every four weeks, is expected to improve patient adherence and provide a new, effective, and safe systemic treatment option for patients with moderate-to-severe AD.
About CMS
CMS is a platform company linking pharmaceutical innovation and commercialization with strong product lifecycle management capability, dedicated to providing competitive products and services to meet unmet medical needs.
CMS focuses on the global first-in-class (FIC) and best-in-class (BIC) innovative products, and efficiently promotes the clinical research, development and commercialization of innovative products, enabling the continuous transformation of scientific research into clinical practices to benefit patients.
CMS deeply engages in several specialty therapeutic fields, and has developed proven commercialization capabilities, extensive networks and expert resources, resulting in leading academic and market positions for its major marketed products. CMS continues to promote the in-depth development in its advantageous specialty fields, strengthening the competitiveness of the cardio-cerebrovascular/gastroenterology/ophthalmology/skin health businesses, bringing economies of scale in specialty fields. Among them, the skin health business (Dermavon) has become a leading enterprise in its field, and is proposed to be listed independently on the SEHK. Meanwhile, CMS continuously promotes the operation and development of its integrated R&D, manufacturing and commercialization chain in Southeast Asia and the Middle East, capturing growth opportunities in emerging markets to support the high-quality and sustainable development of the Group.
Reference:
China Insights Consultancy. Industry report on global and China Dermatology Treatment and Care Industry
Chinese Society of Dermatology, China Dermatologist Association. Clinical pathway for the diagnosis and treatment of moderate to severe atopic dermatitis in China (2023): an expert consensus[J]. Chinese Journal of Dermatology, 2023, 56(11): 1000-1007. DOI: 10.35541/cjd.20230247.
CMS Disclaimer and Forward-Looking Statements
This press release is not intended to promote any products to you and is not for advertising purposes. This press release does not recommend any drugs, medical devices and/or indications. If you want to know more about the diagnosis and treatment of specific diseases, please follow the opinions or guidance of your doctor or other medical and health professionals. Any treatment-related decisions made by healthcare professionals should be based on the patient’s specific circumstances and in accordance with the drug package insert.
This press release which has been prepared by CMS does not constitute any offer or invitation to purchase or subscribe for any securities, and shall not form the basis for or be relied on in connection with any contract or binding commitment whatsoever. This press release has been prepared by CMS based on information and data which it considers reliable, but CMS makes no representation or warranty, express or implied, whatsoever, and no reliance shall be placed on, the truth, accuracy, completeness, fairness and reasonableness of the contents of this press release. Certain matters discussed in this press release may contain statements regarding the Group’s market opportunity and business prospects that are individually and collectively forward-looking statements. Such forward-looking statements are not guarantees of future performance and are subject to known and unknown risks, uncertainties and assumptions that are difficult to predict. Any forward-looking statements and projections made by third parties included in this press release are not adopted by the Group and the Company is not responsible for such third-party statements and projections.
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